Merck · 1 day ago
Associate Principal Scientist – Downstream Vaccines and Advanced Biotechnologies Process R&D
Lansdale, PA
Full-time
Onsite
Senior Level, Lead/Staff
$142K/yr - $224K/yr
5+ years expMerck is a leading company in the pharmaceutical industry, seeking an Associate Principal Scientist for their Vaccine and Advanced Biotechnologies Process R&D department. The role involves leading downstream process development for vaccine programs, collaborating with cross-functional teams, and providing scientific mentorship.
BiotechnologyHealth CareMedicalPharmaceutical
No H1B
Responsibilities
Lead downstream process design and development for conjugate vaccine candidates
Design, execute, and analyze process development experiments to maximize conjugate vaccine production processes, thereby de-risking later stage development and tech transfer
Represent functional area in cross-functional and strategic teams engaged in vaccine development
Lead tech transfer of vaccine bioconjugation processes for clinical and commercial manufacture
Serve as scientific/technical mentor for junior staff, providing technical guidance in the various aspects of downstream bioprocess/bioconjugation development
Support strategic initiatives and innovation in the areas of vaccine and advanced biotechnology process development
Analysis of experiments through analytical techniques including HPLC, light scattering, and spectroscopy
Data interpretation and presentation, manuscript/patent preparation
Qualification
Required
BS, MS or PhD in engineering or bio/chemical sciences: Chemical Engineering, Bioengineering, Biomedical Engineering, Chemistry, Biochemistry, Molecular Biology, Biotechnology
For BS candidates, at least eight (8) years of experience in a pharmaceutical or biotechnology-related position
For MS candidates, at least five (5) years of experience in a pharmaceutical or biotechnology-related position
For PhD candidates, at least three (3) years of experience in a pharmaceutical or biotechnology-related position
Strong scientific and hands-on understanding of downstream bioprocess/bioconjugation unit operations, biotherapeutic and/or vaccine process development and sound understanding of scale-up principles
At least five (5) years of hands-on laboratory experience in downstream bioprocess/bioconjugation development
Prior experience with statistical design of experiments (DOE) and/or algorithmic process optimization
Strong understanding of, or hands-on experience in, cGMP manufacturing
Ability to work effectively both independently and in a team-focused environment
Well-developed organizational, record-keeping, and timeline/resource-mapping skills
Preferred
Experience with biomolecule conjugation (e.g., conjugate vaccines, antibody-drug conjugates), conjugation chemistry and downstream bioconjugate processing
Experience in leading technical development teams and mentoring others
Experience in authoring and reviewing CMC regulatory documentation
Experience with process and technology transfer
Benefits
Medical
Dental
Vision healthcare and other insurance benefits (for employee and family)
Retirement benefits, including 401(k)
Paid holidays
Vacation
Compassionate and sick days
Company
Merck
Merck is a biopharmaceutical company that offers medicines and vaccines for various diseases.
10001+ employees
Funding
Current Stage
Public CompanyTotal Funding
$5.59MKey Investors
Private Capital AdvisorsGavi, the Vaccine Alliance
2018-11-25Post Ipo Equity· $0.59M
2016-01-21Series Unknown· $5M
1980-12-19IPO
Leadership Team
Betty Larson
Executive Vice President and Chief Human Resources Officer
Dean Li
Executive Vice President and President, Merck Research Laboratories
Recent News
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2026-01-22
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