Washington University School of Medicine in St. Louis · 2 days ago
Senior Scientist (Genome Engineering) - Genetics
Washington University Medical Campus
Full-time
Onsite
Senior Level
$63K/yr - $115K/yr
5+ years expWashington University School of Medicine in St. Louis is seeking a Senior Scientist in the Cremins Lab to oversee and implement research projects focused on genome engineering and cell biology. The role involves developing experimental protocols, collaborating with lab members, and training junior scientists while leading multiple research papers and projects.
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Responsibilities
Collaborates on designing, conducting and reporting of research projects
Responsible for deliverables of the Cremins lab genome engineering subTeam – including, but not limited to, conceptual selection of experimental strategies, protocol development, experimental design, validation, and training of other lab members in key bleeding edge experimental cell and molecular biology assays, including degrons/dTAG systems engineered in humans iPSCs, Cas13 RNA editing, dCas9 based CRISPRi, and CRISPRa, and other new cutting edge broadly relevant genome engineering technologies
Builds strong expertise in training in human iPSC differentiation to organoids and monolayer neurons as well as pilots experiments to facilitate neural aging in the lab
Leads multiple papers and major research papers at the center of the laboratories larger goals. Designs, conducts, assists and oversees experiments and original research in the area of neuronal genome regulation with a focus on elucidating structure-function relationships across scales of nucleus, synapses, circuits
Assists PI with NIH required data portal approvals, Grant and University-related paperwork, yearly RRPR reports for every one of the lab’s grants - including coordinating with the subTeam members to get the content assembled
Edits and gives feedback on postdoc and student proposal, grant submission, and manuscript drafts
Collaborates fluidly with computational experts to conduct efficient analyses leading to discovery in mammalian neuron genome structure-function data. In parallel, trains to achieve mastery and excellence in running code written by other members of the lab to analyze genomic and imaging data, for example calling DMLs in methylation data, calling compartments, TADs, subTADs, loops in Hi-C/Micro-C data, or peak calling of Cut&Run and Cut&Tag data
Mentors Junior trainees in scientific endeavors under the purview of the SRI’s expertise and trains new lab members on genome engineering and cellular differentiation
Oversees and writes established SOPs for new and existing molecular sequencing technologies – genome engineering, new and existing computational algorithms – iPSC differentiation to neurons, organoids, and assembloids
Complies with established safety procedures and maintains required documentation on laboratory and specimen conditions (maintaining lab freezer maps and plasmid and antibody maps and reagent storage with excellence to keep a 25 person lab organized with high quality infrastructure)
Performs other duties as assigned
Qualification
Required
PhD or Terminal Degree or Combination of Education and Experience May Substitute for Minimum Education
Postdoctoral (3 Years)
Strong background in culturing induced pluripotent stem cells (iPSCs)
Differentiation of pluripotent cells into neuronal lineages
Genome engineering using CRISPR/Cas9
Molecular biology and biochemistry laboratory techniques (e.g., molecular cloning)
Cell biology approaches (e.g., immunofluorescence, RNA/DNA fluorescence in situ hybridization)
Routine chromatin techniques and sequencing-based technologies (e.g., RNA-seq, ATAC-seq, CUT&Tag/CUT&RUN; Hi-C)
Mentoring and supervising students and trainees
Ability to collaborate fluidly with computational experts
Ability to oversee and write established SOPs for new and existing molecular sequencing technologies
Ability to comply with established safety procedures and maintain required documentation on laboratory and specimen conditions
Preferred
PhD in cell biology, genome engineering/biotechnology, or neuroscience
Excellent communication and interpersonal skills
Independent thinking
Desire to work in a complex and high-energy environment
Experience in CRISPR and other forms of genome engineering
Experience in some combinations of human iPSC culture, brain organoids, neuron characterization, computational biology, or in vivo AAV or lentivirus injections
Some experience with the Python/R programming language, Linux environment, and cluster computing
Excellent organizational and time management skills
Ability to work with a multi-disciplinary team
Benefits
Up to 22 days of vacation, 10 recognized holidays, and sick time.
Competitive health insurance packages with priority appointments and lower copays/coinsurance.
Take advantage of our free Metro transit U-Pass for eligible employees.
WashU provides eligible employees with a defined contribution (403(b)) Retirement Savings Plan, which combines employee contributions and university contributions starting at 7%.
Wellness challenges, annual health screenings, mental health resources, mindfulness programs and courses, employee assistance program (EAP), financial resources, access to dietitians, and more!
We offer 4 weeks of caregiver leave to bond with your new child.
Family care resources are also available for your continued childcare needs.
WashU covers the cost of tuition for you and your family, including dependent undergraduate-level college tuition up to 100% at WashU and 40% elsewhere after seven years with us.
Company
Washington University School of Medicine in St. Louis
WashU Medicine is a leader in improving human health throughout the world.
5001-10000 employees
Funding
Current Stage
Late StageTotal Funding
$381MKey Investors
National Human Genome Research InstituteNational Cancer InstituteNational Institutes of Health
2025-01-21Grant
2024-12-16Grant· $10.8M
2023-05-11Grant· $22.5M
Leadership Team
Camilo Molina
Director of Spinal Deformity and Spinal Oncology
C
Charbel Khoury
Assistant Professor Of Medicine
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