Dyne Therapeutics · 4 days ago
Director, Global Health Economics & Outcomes Research (HEOR)
Waltham, MA
Full-time
Onsite
Director/Executive
$210K/yr - $252K/yr
10+ years expDyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. They are seeking a Director, Global HEOR, to lead the strategy and execution of defining and communicating the value of medicines approaching commercialization, ensuring strong arguments for access to these medicines. The role involves cross-functional collaboration and significant contributions to evidence generation and payer engagement.
BiotechnologyHealth CareMedicalPharmaceutical
Responsibilities
Informing development strategies from HEOR / market access perspective
Represent the HEOR and market access perspective in internal clinical development and regulatory forums
Provide critical input into clinical development plans, including protocol design, endpoint selection, and other aspects of clinical trial evidence generation, to ensure alignment with future payer and HTA expectations
Communication of value to payers and HTA bodies
Lead development of AMCP dossiers for US payers
Lead development of cost-effectiveness models for NICE and other HTA bodies requiring formal cost-effectiveness analyses
Serve as a core team member for HTA submissions outside the US, with responsibility for shaping and stress-testing value narratives included in pricing and reimbursement dossiers and interpreting and recommending evidence to support such narratives, in a way that optimizes both credibility and relevance for payer decision-making
Make substantial contributions to other payer communication materials (e.g., Medical Value Liaison slide decks) and launch readiness activities as needed
Leading real-world evidence strategy and execution of real-world analyses
Lead planning of real-world evidence generation activities to address evidence gaps as needed for informing decision-making by payers, HTA bodies, and clinicians
Oversee execution of real-world data analyses, ensuring analytical rigor and fitness for purpose
Interpret and translate results from real-world analyses into peer-reviewed publications and other external communications intended to meaningfully inform clinical practice and payer/HTA decision-making
Qualification
Required
Bachelor's degree or equivalent experience in a relevant field such as economics, public health, epidemiology, biostatistics, health policy, life sciences, or a related discipline
10+ years of progressive experience in HEOR, health analytics, value demonstration, market access, or a closely related quantitative or scientific field
Demonstrated success leading complex evidence‑generation, modeling, or analytical programs within biopharma, healthcare consulting, payer organizations, or academic research environments
Experience influencing senior leaders and driving strategic decisions through evidence and structured analysis
Analytical ability: Strong reasoning and structured problem‑solving capabilities, with curiosity, persistence, and creativity to tackle complex, open‑ended problems
Sophisticated understanding of evidence: Clear judgment about what different analytical methodologies can and cannot tell you, and what makes an analysis more or less robust
Understanding of value frameworks: Familiarity with decision‑making frameworks that inform how medicines are valued, priced, and reimbursed
Strong mathematical intuition: Deep understanding of how numbers work, how models behave, and how assumptions propagate through analyses
Critical evaluation of scientific literature: Ability to read, interpret, and rigorously critique medical, scientific, and health economics publications
Biological and clinical literacy: Sufficient grounding in biology and clinical science to engage effectively with development teams and external clinical experts
Results orientation: Focus on organizational priorities—balancing rigor with pragmatism and avoiding analysis for analysis' sake
Bias toward solutions and progress: Mindset oriented toward finding solutions, offering alternatives, and maintaining momentum
Preferred
Advanced degrees (Master's, PhD, PharmD, MD) are welcome but not required
Company
Dyne Therapeutics
Dyne Therapeutics is a developer of targeted therapies intended for serious muscle diseases.
51-200 employees
Funding
Current Stage
Public CompanyTotal Funding
$1.67BKey Investors
Hercules CapitalAtlas Venture
2025-12-09Post Ipo Equity· $402.5M
2025-06-30Post Ipo Equity· $230M
2025-06-30Post Ipo Debt· $100M
Leadership Team
John Cox
Chief Executive Officer
Recent News
2026-01-11
2026-01-07
Company data provided by crunchbase