Johnson & Johnson Innovative Medicine · 1 day ago
Principal Scientist, Molecular Biology
Spring House, PA
Full-time
Onsite
Senior Level, Lead/Staff
6+ years expJohnson & Johnson Innovative Medicine is committed to healthcare innovation and seeks a Principal Scientist in Molecular Biology to lead a team in antibody discovery. The role involves managing laboratory operations, executing molecular biology workflows, and collaborating with multidisciplinary teams to advance therapeutic programs.
Pharmaceuticals
Responsibilities
Provide day-to-day in-person guidance and mentoring within the V-Gene Recovery (VGR) team
Lead antibody sequence recovery from selected hits of diverse sources, including hybridoma, single B cells, immune repertoires, and in vitro display platforms
Execute and optimize molecular biology workflows, including Next-Generation Sequencing (NGS) and conventional Sanger sequencing, to enable efficient and accurate antibody discovery
Work with automation experts to automate and streamline NGS workflows, identifying opportunities for process improvements to enhance sequencing accuracy and efficiency
Manage laboratory operations by maintaining equipment, ensuring sufficient inventory of supplies, and overseeing the routine maintenance of NGS instruments and related laboratory equipment
Conduct comprehensive data analysis, interpret sequencing results, and generate detailed reports. Bioinformatics experience is a plus
Present research findings in internal meetings, clearly communicating scientific results and providing insights into data interpretation
Collaborate with multidisciplinary teams across functional areas to advance therapeutic programs, contributing scientific expertise to multiple projects in a dynamic and fast-paced environment
Document work accurately and promptly using Electronic Lab Notebook systems (e.g., Signal) and generate protocols and SOPs
Work closely with stakeholders and project managers to address operational needs and ensure seamless workflow execution
Demonstrate scientific curiosity and problem-solving skills, contributing to innovation and continuous improvement in molecular biology and sequencing workflows
Qualification
Required
Minimum of a Bachelor's degree is required
PhD in Molecular Biology, Biomedical Engineering, Biochemistry or a related field is highly preferred
Minimum 6 years of experience in the pharmaceutical industry and/or academic setting
Team management experience
Proficiency in molecular biology techniques, including PCR, molecular cloning, and plasmid design
Expertise with DNA sequencing (NGS, 10x Genomics, Sanger) and sequence data analysis related to antibody discovery
Preferred
Familiarity with techniques for antibody repertoire analysis and single cell analysis
Knowledge of data management and visualization tools for large datasets, and knowledge with statistical analysis of NGS results
Knowledge on leveraging repertoire sequencing from immunized animals for AI/ML-driven antibody discovery
Company
Johnson & Johnson Innovative Medicine
Johnson and Johnson Innovative Medicine focuses on developing medical solutions for some of the challenging diseases and medical conditions.
10001+ employees
Funding
Current Stage
Late StageLeadership Team
Molly Perkins
VP, Head of Cell & Genetic Medicines Discovery
Recent News
2025-08-14
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