Foresite Labs · 1 day ago
Staff Engineer, High Performance Data & Algorithm Infrasturcture
San Diego, CA
Full-time
Onsite
Senior Level, Lead/Staff
$175K/yr - $185K/yr
7+ years expForesite Labs is a venture-backed, stealth-stage biotechnology company focused on developing novel technologies in clinical genomics. The company is seeking a Senior Staff Software Engineer with expertise in high-performance computing to design and optimize data processing pipelines that enhance performance across various computing systems.
BiopharmaBiotechnologyHealth CareMedical
Responsibilities
Design, build, and optimize high-throughput, low-latency compute pipelines
Profile and tune performance across CPUs, GPUs, memory, storage, and networking
Identify and eliminate bottlenecks in data movement and computation
Work directly with hardware and OS configuration to achieve deterministic, repeatable performance
Configure and tune Linux systems for high-performance workloads
Customize and tune Linux kernel parameters (scheduler, NUMA, IRQs, huge pages, IOMMU, etc.)
Tune CPU and BIOS parameters (power states, frequency scaling, SMT, NUMA, memory timing)
Manage and optimize DMA paths between devices and system memory
Minimize context switches, cache misses, and system jitter
Develop and optimize GPU-accelerated compute pipelines using CUDA
Optimize memory transfers between host and GPU (pinned memory, zero-copy, GPUDirect where applicable)
Tune kernel launches, memory access patterns, and occupancy
Configure and manage GPU drivers, runtime, and system-level settings for maximum throughput
Profile GPU workloads using tools such as Nsight Systems and Nsight Compute
Optimize high-speed data ingestion and offload to HPC systems
Work with low-latency and high-bandwidth networking technologies (e.g., RDMA, InfiniBand, high-speed Ethernet)
Minimize data transfer latencies across network, PCIe, and memory boundaries
Design zero-copy or near-zero-copy data paths where possible
Implement and optimize digital signal processing algorithms, including: FFTs, Deconvolution, Thresholding and detection algorithms
Optimize DSP workloads for CPU vectorization and GPU acceleration
Balance numerical accuracy, latency, and throughput constraints
Qualification
Required
BS/MS in Computer Science or Engineering
7+ years of professional software engineering experience (or equivalent depth)
Strong background in high-performance computing or performance-critical systems
Expert-level Linux experience, including kernel and system tuning
Deep experience with GPU computing and CUDA (required)
Strong systems programming skills in C/C++ (and/or Rust)
Solid understanding of computer architecture: CPU caches, NUMA, memory hierarchies, PCIe and DMA, GPU architectures
Extensive experience profiling and tuning complex systems
Comfortable using tools such as perf, ftrace, eBPF, valgrind, Nsight, and similar
Ability to reason quantitatively about latency, bandwidth, and throughput
Practical experience implementing DSP algorithms in production systems
Strong understanding of FFTs, convolution/deconvolution, filtering, and thresholding
Ability to optimize numerical algorithms for real-time or near-real-time constraints
Preferred
Experience with RDMA, GPUDirect RDMA, or other hardware offload technologies
Experience with custom kernel builds or kernel module development
Familiarity with real-time or low-latency Linux variants
Experience deploying HPC workloads at scale
Background in scientific computing, signal processing, or computational physics
Benefits
Competitive compensation and equity package
Comprehensive benefits
Flexibility to support work-life integration
Company
Foresite Labs
Foresite Labs is a biotechnology company. It is a sub-organization of Foresite Capital.
11-50 employees
H1B Sponsorship
Foresite Labs has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (2)
2022 (1)
Funding
Current Stage
Early StageLeadership Team
Alex Blocker
CTO and Chief Data Scientist
Uplaksh Kumar
COO Foresite Labs and Venture Partner Foresite Capital
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