Neurocrine Biosciences · 1 day ago
Senior Principal Scientist, DMPK Translational PKPD Modeling
San Diego, CA
Full-time
Onsite
Senior Level, Lead/Staff
$157K/yr - $214K/yr
7+ years expNeurocrine Biosciences is a leading neuroscience-focused biopharmaceutical company dedicated to discovering and developing life-changing treatments for patients. The role involves designing and implementing mechanistic PK/PD models to support the company's pre-clinical biologics portfolio and collaborating with various stakeholders to enhance the DMPK group's capabilities.
BiotechnologyHealth CarePharmaceutical
Responsibilities
Independently develop PK/PD models that enhance decision-making for biologics target and candidate selections and inform translational research strategies for biologics
Use modeling and simulation to predict human efficacious dose/dose regimen and influence selection of Development Candidate
Design pharmacokinetic studies, analyze and interpret data, and clearly communicate results to teams and management
Leverage literature data or propose fit for purpose experiments to validate models or test model-generated hypotheses
Effectively collaborate with scientists within and outside the functional area (biologists, protein engineering scientists, clinical pharmacologists)
Contribute to the overall translational research strategy by integrating PK/PD and target engagement considerations into team strategy and decision-making
Prepare clear technical reports and oral presentations
Develop broad knowledge in the field of expertise and enhances internal capabilities of the group
Qualification
Required
PhD in Biochemistry, Pharmacokinetics, Pharmaceutical Sciences, Biochemical Engineering or closely related discipline with a specific focus on PK and PK/PD modeling and 7+ years of experience in the industrial discovery and development of small and large molecular therapeutics; or MS with 13+ years of industry experience
Theoretical and practical knowledge of pharmacokinetics and PK/PD modeling
Experience using one or more commercially available modeling and simulation platforms (NONMEM, MATLAB, SimBiology, Simcyp etc.)
Proficiency with scriptable modeling and simulation language (e.g., R, MATLAB, Julia)
Proficiency with PBPK modeling applied to biologics research and development
Experience with computational tools used for validation and verification of mechanism-based models (e.g., parameter estimation, sensitivity analysis, virtual population/patient simulations)
Evaluate and apply innovative PK and PK/PD approaches to predict human PK, using modeling as a tool to help generate hypotheses, design studies, inform clinical plans, and support registration
Ability to build effective working relationships and influence others both inside and outside the department
Preferred
Experience in mechanism-based PK/PD modeling of therapeutic proteins is highly desired
Working knowledge in immunology is highly desired
Benefits
Annual bonus with a target of 30% of the earned base salary
Eligibility to participate in our equity based long term incentive program
Retirement savings plan (with company match)
Paid vacation
Holiday and personal days
Paid caregiver/parental and medical leave
Health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans
Company
Neurocrine Biosciences
Neurocrine Biosciences engages in the discovery and development of drugs for the treatment of neurological and endocrine-related diseases.
1001-5000 employees
H1B Sponsorship
Neurocrine Biosciences has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (16)
2024 (9)
2023 (8)
2022 (2)
2021 (5)
2020 (6)
Funding
Current Stage
Public CompanyTotal Funding
$260MKey Investors
Venrock
2015-02-19Post Ipo Equity· $250M
2009-12-17Post Ipo Equity· $10M
1996-05-31IPO
Leadership Team
Matt Abernethy
Chief Financial Officer
D
Dimitri Grigoriadis
VP, Research
Recent News
BioWorld Financial Watch
2026-01-16
Company data provided by crunchbase