Insmed Incorporated · 1 day ago
Senior Scientist, Discovery Pharmacology
Joint Training and Training Development Center, NJ
Full-time
Onsite
Mid, Senior Level
$127K/yr - $166K/yr
4+ years expInsmed Incorporated is a global biopharmaceutical company dedicated to transforming the lives of patients with serious and rare diseases. They are seeking a highly motivated Senior Scientist to lead the development and optimization of in vitro assays and collaborate cross-functionally to support downstream analyses from in vivo studies.
BiotechnologyMedicalPharmaceutical
Responsibilities
Lead cell-based assay development, perform efficacy assessment across primary and follow-up compound screens, and support data-driven decisions for Insmed projects
Isolate and culture primary immune cells (neutrophils, hematopoietic stem/progenitor cells, mouse bone-marrow progenitors) and maintain common lines (e.g., PLB985, HL-60, THP-1, RAW264.7, Jurkat cells) and other relevant cell lines for in vitro/ex vivo assays
Plan and execute experiments using protein-based assays (e.g., Western blotting, ELISA, Luminex multiplex immunoassays)
Perform immunofluorescence staining in cultured cells as well as immunohistochemistry on tissue sections
Conduct microscopy and analysis in partnership with computational scientists, help transition to a high-throughput, AI-driven workflow
Execute multicolor flow cytometry across immune and non-immune cell types, and perform high-purity FACS sorting of rare populations
Support downstream analyses from in vivo studies, including sample collection, processing, and ex vivo measurements
Maintain accurate, detailed, and timely electronic records of method development, experimental data, analyses, and summaries, and generate internal technical reports as needed
Perform data QC and statistical analyses to ensure accuracy, completeness, and validity, using Excel, XLfit, GraphPad Prism, and FlowJo
Conduct critical literature reviews to inform study design and program strategy
Ensure proper maintenance of laboratory equipment
Present scientific results at internal and external meetings as needed
Qualification
Required
PhD with 4+ years of experience in molecular and cellular biology, immunology, or a related field
Strong foundation and proven expertise in innate immunity, and in particular neutrophil biology, are required
Must have hands-on experience with cell culture and standard molecular biology assays, with deep knowledge of developing and optimizing in vitro assays to support target validation
Must have hands-on expertise in imaging techniques such as fluorescence microscopy, confocal microscopy, and high-content imaging systems
Strong hands-on experience with immunofluorescence staining and immunohistochemistry is required
Clear, effective communication (verbal and written) and strong problem-solving skills are required
A high degree of organization and time management skills, with meticulous attention to detail to ensure clarity, accuracy, and concision, are required
A strong sense of enthusiasm, autonomy, and self-motivation is required
Ability to work collaboratively and efficiently in a team environment is essential
Must successfully exhibit Insmed's five (5) core corporate values: Passion, Accountability, Collaboration, Integrity and Respect
Preferred
Experience working with downstream sample processing from preclinical animal models is a strong plus
Experience handling animals and/or developing or evaluating animal models is a strong plus
Familiarity with disease areas including respiratory, immune-mediated, and autoimmune diseases is a strong plus
Benefits
Comprehensive medical, dental, and vision coverage and mental health support, annual wellbeing reimbursement, and access to our Employee Assistance Program (EAP)
Generous paid time off policies, fertility and family-forming benefits, caregiver support, and flexible work schedules with purposeful in-person collaboration
401(k) plan with a competitive company match, annual equity awards, and participation in our Employee Stock Purchase Plan (ESPP), and company-paid life and disability insurance
Company Learning Institute providing access to LinkedIn Learning, skill building workshops, leadership programs, mentorship connections, and networking opportunities
Employee resource groups, service and recognition programs, and meaningful opportunities to connect, volunteer, and give back
Company
Insmed Incorporated
Insmed is a people-first global biopharmaceutical company striving to deliver first- and best-in-class therapies to transform the lives of patients facing serious diseases.
1001-5000 employees
H1B Sponsorship
Insmed Incorporated has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (20)
2024 (6)
2023 (14)
2022 (8)
2021 (1)
2020 (5)
Funding
Current Stage
Public CompanyTotal Funding
$4.56BKey Investors
CureDuchenne Ventures
2025-06-11Post Ipo Equity· $750M
2024-05-30Post Ipo Equity· $650M
2023-05-08Post Ipo Equity· $0.5M
Leadership Team
Will Lewis
Chairman and Chief Executive officer
Walter R. Perkins
Chief Technology Officer
Recent News
2026-01-13
2026-01-11
Company data provided by crunchbase