Flagship Pioneering · 6 hours ago
Senior Scientist, Nucleic Acid Chemistry
Cambridge, MA USA
Full-time
Onsite
Mid, Senior Level
$126K/yr - $182K/yrFlagship Pioneering is developing novel delivery technologies to redefine genetic medicine. They are seeking a Senior Scientist in Nucleic Acid Chemistry to innovate and build next-generation Programmable Medicines, contributing to molecular design, synthesis optimization, and assay development.
FinanceFinancial ServicesVenture Capital
Responsibilities
Contribute to Nucleic Acid Chemistry innovation, aligned with the company’s core strategic goals. This role is the first dedicated hire in our Chemistry team, so we’re not just looking for a pair of hands. We’re looking for someone who can think critically and creatively about nucleic acids to influence the company’s scientific directions, including:
Molecular design
Synthesis scheme optimization
Assay design
Plan and execute Nucleic Acid Chemistry experiments. Along with ideation, we’re looking for someone who’s excited to roll up their sleeves and pursue benchwork science. This is primarily a bench role, at least at the outset. Key skillsets include:
Preparation, purification, and validation of small molecules (NMR, LC/MS, HPLC, etc.)
Reactions of small molecules with nucleic acids, including purification and validation
CRO management for small molecule synthesis
Qualification
Required
PhD in Chemistry or Biochemistry with deep experience in nucleic acid chemistry (e.g., synthesizing and applying chemical probes of DNA, developing small molecules to profile RNA structure, or creating tools to study nucleic acid modifications)
Expertise in methods for analyzing and purifying compounds (NMR, HPLC, LC-MS, etc.)
Fluency in standard molecular biology methods for producing and assaying nucleic acids (PCR, IVT, gel and capillary electrophoresis, etc.)
Experience with organic synthesis of small molecules
Caring deeply about your work and your colleagues
Passion for challenging, fast-paced, ever-changing science
Superior attention to detail and execution of experiments, both personally and via CROs
Technical expert: Your background is in Chemistry or Biochemistry, and you have relevant experience in nucleic acid innovation, production, purification, and assay development
Mission-driven scientist: You have an unquenchable spirit to build something new that will create huge impact for the world
Relentless pioneer: You thrive in new and unknown territory - capable of charting comprehensive but actionable plans, executing rapidly and iteratively to make progress, and reliably delivering decisive readouts on time
Team player: You flourish in collaborative work environments with other highly skilled individuals. You readily support your colleagues' challenges & celebrate their victories
Effective communicator: You not only understand the science but are capable of conveying technical information in a clear, concise, and decisive manner
Benefits
Healthcare coverage
Annual incentive program
Retirement benefits
Broad range of other benefits
Company
Flagship Pioneering
Flagship Pioneering is a venture capital firm that invests in life sciences and healthcare companies.
Founded in 2000
501-1000 employees
H1B Sponsorship
Flagship Pioneering has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (8)
2024 (4)
2023 (4)
2022 (4)
2021 (1)
Funding
Current Stage
Late StageLeadership Team
Noubar Afeyan
Founder and CEO
Chuck Carelli
Chief Financial Officer
Recent News
2026-01-16
2026-01-16
Company data provided by crunchbase