San Diego Supercomputer Center · 8 hours ago
Staff Research Associate - 138091
San Diego, CA
Full-time
Onsite
Lead/Staff
$30.32/hr - $48.78/hrThe San Diego Supercomputer Center is a prestigious institution focused on advancing research and innovation in health sciences. They are seeking a Staff Research Associate to design and engineer bacteria for manipulating the gut microbiome, contributing to research on physiological homeostasis and disease. The role involves working with animal models and requires creativity, initiative, and the ability to work in a fast-paced research environment.
Big DataDatabaseInformation Technology
Responsibilities
Focus on designing and engineering bacteria to functionally manipulate the gut microbiome and host physiology
Study the effects of specific bacterial functions and test whether functional manipulations of the gut microbiome can lead to therapeutic or diagnostic agents
Perform functional manipulation of the luminal environment with a novel engineered bacteria platform
Carry out a variety of technical procedures with minimal instruction or supervision
Design pre-clinical studies with the aim of testing the role of the gut microbiome in mouse models of cancer and inflammation
Design circadian biology studies in mouse models of cancer
Conduct tissue and cell culture, sterile techniques, isolation and culture of primary cells and cell lines for oncology and immunology research
Develop and perform biochemical and bacterial cell-based assays, design/troubleshoot/validate assays and critically analyze assay data
Work independently or collaboratively on a research project, maintaining a high level of motivation to contribute to cutting-edge research
Provide work direction to undergraduate student lab employees and train others in various lab techniques and procedures
Qualification
Required
Theoretical knowledge in a related science field as typically attained through a Bachelor's degree, or an equivalent combination of education and laboratory experience
Experience in animal models of cancer including transgenic mouse models and implantable models with the ability to carry out a variety of technical procedures with minimal instruction or supervision
Experience in designing pre-clinical studies with the aim of testing the role of the gut microbiome and its function in mouse models of cancer and inflammation with the ability to carry out a variety of technical procedures with minimal instruction or supervision
Experience in designing circadian biology studies in mouse models of cancer
Experience in tissue and cell culture, sterile techniques, isolation and culture of primary cells and cell lines for oncology and immunology research
Experience in tumor immunology and inflammation
Experience in prokaryotic recombinant gene expression, bacterial physiology, genetics, and strain construction
Excellent technical abilities in microbiology with experience in working with multiple strains; familiarity with current molecular techniques and software, including the ability to design/construct plasmids, genetically manipulate bacterial strains, and analyze sequence data for cloning purposes with prior experience in recombinant gene expression in bacteria, proficiency in cloning/plasmid construction, and bacterial strain construction
Experience in the development and performance of biochemical and bacterial cell-based assays as well as the ability to design/troubleshoot/validate assays and critically analyze assay data
Experience with molecular biology techniques (e.g., PCR, qRT-PCR, DNA/RNA purification, gel electrophoresis, protein isolation) with the ability to carry out a variety of technical procedures with minimal instruction or supervision
Familiarity with handling BSL-2 bacteria, mammalian cell culture, and sterile technique
Demonstrated excellent organizational skills including ability to keep clear and accurate records, organize a varied workload, and give oral presentations on the progress of research
Enthusiasm for learning and genuine interest in scientific research. Willingness and ability to learn new skills, research methods, and scientific principles. Ability to take direction, be detail-oriented and follow step-wise instruction
Demonstrated ability to work independently or collaboratively on a research project. Ability to maintain a high level of motivation to contribute to cutting edge research, and seek and learn new experimental methods as required
Demonstrated successful, positive interpersonal oral and written communication skills using tact, diplomacy, discretion, and flexibility with diverse personalities and situations. Skill to interact effectively with faculty, academics, students, and staff including those of diverse ethnicity, culture, and foreign nationals
Demonstrated ability to provide work direction to undergraduate student lab employees. Skill to train others in various lab techniques and procedures (safety precautions, preparation of media, dishwashing, equipment usage, laboratory maintenance, etc)
Experience and skill with MS Office programs, Google Docs, file-making, spreadsheet, and graphics software; willingness and ability to update and increase PC skills and knowledge as needed
Demonstrated ability to maintain confidentiality in matters related to work
Knowledge of Material Safety Data Sheets, hazard communication, and Injury and Illness Prevention Program; safety precautions including appropriate clothing and shoes, safe handling of chemicals, and use of protective items such as gloves and goggles
Preferred
Experience in generating RNA and DNA libraries for next generation sequencing
Experience in preparing multiplex immunoassays and using multiplex systems
Basic knowledge and experience of accounting, billing practices, purchasing and reimbursement procedures. Ability to proactively and appropriately facilitate the maintenance of all lab supplies and equipment, maintain steady levels of lab supplies, and organize purchasing records. Knowledge of UC San Diego Health purchasing procedures
Experience working in gut microbiome experiments including with germ-free mice
Experience maintaining mouse colonies and genotyping mice for the lab including maintenance of transgenic lines and knowledge of humane methods of caring for lab animals. Sensitivity to the needs of laboratory animals in compliance to AAALAC standards
Experience with immunohistochemistry, staining, microscopy, and preparing tissue for histology
Experience with gel electrophoresis and protein isolation
Company
San Diego Supercomputer Center
SDSC enables science and engineering discoveries through advances in computational science and data-intensive, high-performance computing.
Founded in 1985
201-500 employees
Funding
Current Stage
Growth StageTotal Funding
unknownKey Investors
National Science Foundation
2024-12-05Grant
Leadership Team
Ilkay Altintas
Division Director, Cyberinfrastructure and Convergence Research and Education
Recent News
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