Oxford BioTherapeutics · 18 hours ago
Scientist/Sr./Principal Scientist, ADC & Translational Research
San Jose, CA
Full-time
Onsite
Senior Level, Lead/Staff
6+ years expOxford BioTherapeutics (OBT) is a clinical stage oncology company focused on developing innovative therapies for cancer treatment. They are seeking a Scientist/Sr/Principal Scientist experienced in ADC and Translational Research to contribute to their Oncology ADC pipeline, collaborating with various teams to develop first-in-class ADC therapies.
BiotechnologyGeneticsHealth CareHealth DiagnosticsTherapeutics
Responsibilities
Design and execute key in vitro and ex vivo experiments independently to identify and characterize novel tumor-associated antigens and evaluate ADCs with different payloads and DARs that inform and enable project progression
Utilize diverse cutting-edge molecular and cell-based techniques including antibody internalization rate analysis, antigen recycle rate analysis, antigen density analysis, various effector-dependent and independent cytotoxicity assays in high throughput and real time manners, ELISA, multiplex cytokine immunoassays, immunogenic cell death, (ICD), quantitative multi-colored flow cytometry analysis (FlowJo), GraphPad Prism, CyTOF, gene set enrichment analysis, bioanalytical pharmacokinetic (PK) and pharmacodynamic (PD) assays, toxicity profiling screening, immunogenicity, ADA evaluation
Collaborate cross-functionally with discovery, bioinformatics, protein sciences, and translational teams to drive ADC candidate selection and optimization
Conduct and interpret binding affinity assays, stability studies, and functional characterization of engineered antibodies
Expand in-house capabilities for ADC toxicity by implementing new techniques and cutting-edge technologies
Apply ML/AI approaches to guide antibody sequence optimization, develop predictive models, and analyze large datasets (e.g., sequence-function relationships, developability metrics)
Cultivate a culture of scientific excellence, urgency, critical thinking, and continuous learning
Independently devise, execute, and analyze hypothesis-driven translational research experiments to identify PD biomarkers, mechanisms of sensitivity and resistance and test novel drug-combinations to further advance the OBT ADC pipeline
Lead programs by executing lead optimization strategies and driving discovery goals
Prepare patent applications and publish impactful research
Supervise, mentor and train less experienced employees
Qualification
Required
PhD. in cancer biology, immuno-oncology, pharmacology, pharmaceutical sciences, or related discipline
Master's degree with 6-10+ years of experience or bachelor's degree with 8-12+ years of experience in the biopharmaceutical industry
Post-doctoral training (4+ years) or MD in oncology or related field in academia or pharma industry
Self-motivated with a strong desire to uncover novel biology and develop new therapeutics
Experience with primary human cellular/tissue-based assays to guide/inform indication selection, biomarker discovery and mechanism-of-action
Experience with quantitative FACS using multiple color-labeled markers by design
Deep-understanding statistical design and analysis (i.e., GraphPad Prism) for preclinical experiments
Ability to identify and plan critical experiments aligned with team objectives
Strong problem-solving skills to address complex challenges with innovative and effective approaches
Experience working in matrix teams to deliver defined objectives
Highly effective interpersonal skills and collaborative mindset with the ability to communicate with diverse stakeholders and facilitate critical decision making
Strong written and verbal communication skills to present to both internal and external collaborators
Benefits
Medical, dental and vision insurance
FSA (Flexible Spending Account)
STD, LTD, Basic Life, Supplemental Life and AD&D Insurance
401(k) Plan
Up to 120 hours of Paid Time Off in your first year (increasing with tenure)
5 sick days per year
11 paid holidays
Employee Referral Bonus Program
Annual training budget for professional development
Annual bonus program
New hire stock options
Team building events and activities
Company
Oxford BioTherapeutics
Oxford BioTherapeutics develops medicines for cancer and companion diagnostics for selected antibody programs.
11-50 employees
H1B Sponsorship
Oxford BioTherapeutics has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (2)
2020 (1)
Funding
Current Stage
Early StageTotal Funding
$33.22MKey Investors
Calculus CapitalOxford Finance LLCSilicon Valley Bank
2021-01-01Series Unknown
2018-08-03Series Unknown· $2.6M
2017-01-26Debt Financing· $10M
Leadership Team
Abderrahim Fandi, MD PhD
Chief Medical Officer
Joyce B.
Human Resources and Office Business Partner
Recent News
2025-12-15
MarketScreener
2025-12-10
Company data provided by crunchbase