Baylor College of Medicine · 16 hours ago
Staff Scientist
Houston, TX
Full-time
Onsite
Senior Level, Lead/Staff
3+ years expBaylor College of Medicine is seeking a highly motivated individual to join a research laboratory at the Jan and Dan Duncan Neurological Research Institute. The Staff Scientist will investigate the genetic and molecular mechanisms underlying neurological disorders and support multiple research projects related to Alzheimer’s disease and Parkinson’s disease.
EducationHigher EducationPharmaceutical
Responsibilities
Maintain mouse colonies, including genotyping, breeding cage setup, and conducting mouse behavioral experiments
Conduct mechanistic studies of candidate small-molecule compounds using biochemical, cellular, and molecular biology techniques
Design, optimize, and execute in vitro and in vivo experiments to support target validation, pathway analysis, and mechanistic hypothesis testing
Perform mouse-based preclinical studies, including compound formulation, dosing regimen design, pharmacodynamic (PD) biomarker assessment, and in vivo efficacy evaluation in Alzheimer’s disease mouse models
Utilize iPSC-derived cellular models to evaluate compound activity, target engagement, cytotoxicity, and disease relevance, supporting translational interpretation of preclinical data
Support the Principal Investigator and pre- and postdoctoral trainees with ongoing scientific research projects
Maintain recombinant DNA laboratory protocols, including renewals and regulatory submissions
Oversee laboratory equipment, including maintenance coordination and service contracts
Document, analyze, and report experimental results to the Principal Investigator in a timely and accurate manner
Attend departmental seminars, attend weekly lab meetings/journal club meetings
Perform other job-related duties as assigned
Qualification
Required
Doctoral Degree. Experience may not be substituted in lieu of degree
Three years of post doctoral research experience
Experience working with mouse models
Experience with small molecule compounds
Company
Baylor College of Medicine
Baylor College of Medicine, located in the Texas Medical Center, is a health sciences university located in Houston, Texas
5001-10000 employees
H1B Sponsorship
Baylor College of Medicine has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (252)
2024 (208)
2023 (164)
2022 (196)
2021 (126)
2020 (136)
Funding
Current Stage
Late StageTotal Funding
$10.85MKey Investors
National Human Genome Research InstituteNational Heart, Lung and Blood InstituteCancer Prevention and Research Institute of Texas
2024-12-05Grant· $3.5M
2024-09-26Grant
2024-09-19Grant
Leadership Team
Paul Klotman
President, CEO and Executive Dean
Peggy Smith
Professir and CEO. Teen Health Clinics
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