Merck · 4 hours ago
Senior Scientist, Molecular Discovery
USA - California - San Diego (Science Park Road)
Full-time
Hybrid
Mid, Senior Level
$106K/yr - $167K/yr
4+ years expMerck is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. They are seeking a Senior Scientist with expertise in antibody expression and production workflows to contribute to the discovery and development of novel therapeutics in the field of Inflammation and Immunology.
BiotechnologyHealth CareMedicalPharmaceutical
Responsibilities
Design, engineer and characterize innovative biologics including antibodies and multi-specific molecules
Protein production and purification including antibodies, target antigens and the critical protein reagents required for biologics discovery
Biophysical characterization of novel therapeutic protein designs
Exploring and applying new protein production technologies and strategies as needed
Drive innovation by contributing to exploratory programs and platform technology development
Collaborating with other teams to integrate new developments into future projects
Qualification
Required
Bachelor's (with 7 years), Master's (with 4 years) or Ph.D. in biochemistry, structural biology or related discipline with relevant laboratory experience described below
Deep experience in protein structure/function and expert level utilization of computational tools to drive structure- and/or AI/ML-based protein design
Demonstrated track record of engineering proteins with improved function or properties towards design targets
Experience in designing protein expression constructs including vector selection, cassette design, cloning and validation
Hands-on experience with cloning techniques, including Gibson assembly, plasmid characterization, and protein expression
Proven proficiency in protein production workflows, including purification and analytical characterization
Hands-on experience with mammalian cell culture and expression platforms (CHO, HEK293)
Demonstrated strong communication skills and ability to multi-task and work collaboratively in a cross-functional team environment
Excellent organizational skills and High attention to detail
Preferred
Experience with antibody-based therapeutic modalities (mAb, VHH, bispecific Ab, antibody fusions)
Experience in stable expression systems
Expertise in cell culture process optimization to improve titer and productivity
Experience with high throughput technologies and automation platforms
Benefits
Medical
Dental
Vision healthcare and other insurance benefits (for employee and family)
Retirement benefits, including 401(k)
Paid holidays
Vacation
Compassionate and sick days
Company
Merck
Merck is a biopharmaceutical company that offers medicines and vaccines for various diseases.
10001+ employees
Funding
Current Stage
Public CompanyTotal Funding
$5.59MKey Investors
Private Capital AdvisorsGavi, the Vaccine Alliance
2018-11-25Post Ipo Equity· $0.59M
2016-01-21Series Unknown· $5M
1980-12-19IPO
Leadership Team
Betty Larson
Executive Vice President and Chief Human Resources Officer
Dean Li
Executive Vice President and President, Merck Research Laboratories
Recent News
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2026-01-22
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