Sanofi · 22 hours ago
Principal Scientist Quantitative Systems
Cambridge, MA
Full-time
Onsite
Senior Level, Lead/Staff
$122K/yr - $177K/yr
4+ years expSanofi is an innovative global healthcare company committed to improving people’s lives through science. The Principal Scientist in Quantitative Systems will support R&D by developing computational models to accelerate drug discovery and development.
Health CareLife SciencePharmaceuticalTherapeutics
Responsibilities
Function as part of a team to develop and apply multiscale computational models of complex diseases based on detailed biological mechanistic knowledge to support model-informed drug discovery & development
Survey literature to gain understanding of critical physiological processes to be represented, and identify suitable mechanistic elements, data, parameters and assumptions to be included
Identify and analyze suitable internal preclinical and clinical data to inform modeling activities
Analyze simulation results and identify appropriate strategies to resolve issues pertaining to model performance and accuracy
Maintain extensive documentation of model development process, and data analysis
Maintain quantitative systems pharmacology expertise through comprehensive education
Undefined
Communicate modeling predictions to key stakeholders
Qualification
Required
PhD in systems pharmacology/biology, computational biology, biomedical engineering, or a related field with a strong record of productivity demonstrated through publications and scientific presentations with at least 2 years of Postdoctoral experience in disease modeling/QSP
Master's degree with 4+ years of relevant industry experience, OR
Proficiency in mathematical modeling using differential equations
Extensive experience in computational tools such as MATLAB, Julia and R (MATLAB preferred)
Excellent oral and written communication skills
Ability to quickly learn pathophysiology in indications of interest, and treatment approaches in immunology
Highly motivated, detail-oriented, and independent researcher
Able to thrive in a collaborative, multi-disciplinary team environment
Strong commitment to on-the-job-training
Preferred
Experience in drug discovery/development a plus, especially in bioinformatics or pharmacometrics
Knowledge of Immunology
Benefits
High-quality healthcare
Prevention and wellness programs
At least 14 weeks’ gender-neutral parental leave
Company
Sanofi
Sanofi is a global biopharma company focused on prescription drugs, vaccines, and treatments for chronic, rare, and infectious diseases.
10001+ employees
H1B Sponsorship
Sanofi has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (101)
2024 (68)
2023 (59)
2022 (78)
2021 (38)
2020 (38)
Funding
Current Stage
Public CompanyTotal Funding
$6.97BKey Investors
Blackstone Life SciencesEvotec
2025-10-28Post Ipo Debt· $3B
2025-06-17Post Ipo Debt· $1.74B
2025-03-05Post Ipo Debt· $1.59B
Leadership Team
Paul Hudson
Chief Executive Officer
Francois-Xavier Roger
Chief Financial Officer
Recent News
2026-01-23
2026-01-23
2026-01-23
Company data provided by crunchbase