Arbor Biotechnologies · 5 hours ago
Senior Project Manager, Program & Portfolio Management
Cambridge, MA
Full-time
Hybrid
Senior Level
5+ years expArbor Biotechnologies is a next-generation gene editing company focused on developing novel therapeutics for genetic conditions. They are seeking a highly motivated Senior Project Manager to drive cross-functional program execution and deliver strategic, data-driven insights that influence portfolio decisions.
Artificial Intelligence (AI)BiopharmaBiotechnologyLife Science
Responsibilities
Ensure our scientific teams have the structure, alignment, and visibility needed to deliver on high priority R&D milestones
Provide leadership with actionable insights that drive portfolio decisions and resource allocation
Help build and mature Arbor’s project and portfolio management discipline as the company scales
Lead planning, execution, and tracking for cross-functional R&D programs, partnering with Research, Development, CMC, Regulatory, Clinical, and other stakeholders
Build, own, and maintain integrated program plans, timelines, dependencies, and risk registers
Orchestrate core team meetings, governance discussions, and executive updates—providing clarity, surfacing issues early, and enabling timely decisions
Proactively identify risks, resource constraints, and trade-offs; recommend mitigation strategies informed by scenario and sensitivity analysis
Ensure program objectives remain aligned with broader portfolio strategy and corporate priorities
Develop and maintain forecasting models for timelines, resources, milestones, probability-adjusted scenarios, and decision paths
Conduct competitive intelligence (CI) and landscape monitoring; integrate internal and external insights into program and portfolio recommendations
Create dashboards, analyses, and materials that provide leadership with clear, data-driven decision support
Partner with program leads and leadership to evaluate program prioritization, investment cases, and strategic options
Serve as a translator between scientific teams and business leadership - distilling complex concepts into clear plans, insights, and narratives
Drive consistency in project management tools, templates, and processes; contribute to maturing our PMO and portfolio capabilities
Enable a culture of transparency, accountability, and cross-functional collaboration
Qualification
Required
MBA, MS, or equivalent advanced training providing strong analytical and/or financial modeling foundations
Bachelor's degree in a scientific discipline (e.g., biology, biochemistry, bioengineering, or related field)
A minimum of 5 years' of relevant experience
Proven project management experience in a complex, fast moving, cross-functional environment
Demonstrated analytical capabilities: forecasting, scenario modeling, financial or strategic analysis
Ability to collaborate effectively with scientific teams while communicating clearly with nontechnical audiences
Strong organizational, critical thinking, and problem solving skills
Preferred
Experience working within biotechnology, pharmaceutical R&D, or life sciences
Background supporting research through early development programs
Familiarity with portfolio management, competitive intelligence, or corporate strategy in a biotech setting
Experience building dashboards or working with project/portfolio management systems
Company
Arbor Biotechnologies
Arbor Biotechnologies is a biotechnology company specializing in next-generation gene editing therapeutics to treat genetic diseases.
51-200 employees
Funding
Current Stage
Growth StageTotal Funding
$304.5M2025-03-18Series C· $73.9M
2021-11-09Series B· $215M
2017-06-01Series A· $15.6M
Leadership Team
Devyn Smith
Chief Executive Officer, CEO
David Scott
Co-Founder
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