Lycia Therapeutics · 14 hours ago
Research Associate II, Biologics
South San Francisco, CA
Full-time
Onsite
Entry, Mid Level
$95K/yr - $105K/yr
2+ years expLycia Therapeutics is a biotechnology company focused on developing therapeutics that target difficult-to-treat diseases. They are seeking a Research Associate II to generate and characterize molecules to support early discovery research efforts, working cross-functionally within an innovative research organization.
BiotechnologyHealth CareLife Science
Responsibilities
Conduct protein characterization using SDS-PAGE, HPLC, LC/MS, DLS, and other biophysical/analytical methods
Generate bispecific antibodies through controlled Fab-arm exchange (cFAE)
Execute secondary protein purification (IEX, SEC, HIC) when necessary
Biotinylation and fluorescent dye conjugation of antibodies and proteins
Conducts biolayer interferometry (BLI) assays to evaluate antibody-protein interactions
Prepare solutions for binding assessments and in vivo studies through formulation and concentration adjustment
Update and maintain protein inventories as well as accurate and timely documentation of experimental work in electronic laboratory notebooks (ELNs)
Contribute to troubleshooting processes, data analysis, and interpretation
Opportunity to represent functional area through presentation of data during research team meetings or broader company-wide meetings
Conducts routine maintenance, calibration, and troubleshooting of laboratory instruments as needed
Qualification
Required
BS in Biology, Biochemistry, or related field with at least 2+ years of relevant experience OR MS with 0+ years of relevant experience
Previous industry experience is strongly preferred
Proficiency with FPLC systems (e.g., AKTA) and associated software (e.g., Unicorn)
Experience in characterizing recombinant proteins, particularly monoclonal/bispecific antibodies, and associated analytical techniques (SDS-PAGE, HPLC, LC/MS, DLS, BLI)
Basic understanding of protein conjugation technologies (NHS chemistry, enzymatic conjugation, fluorescent dye labeling) and related QC is a plus
Demonstrates strong organizational skills and meticulous attention to detail to manage experimental workflows, while effectively communicating findings across multidisciplinary teams
Ability to work both independently and collaboratively in a team-oriented research environment
Benefits
Annual bonus
Equity
Generous benefits package
Company
Lycia Therapeutics
Lycia Therapeutics is a biotechnology company that focuses on developing technology that utilizes lysosome-targeting chimeras.
11-50 employees
H1B Sponsorship
Lycia Therapeutics has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (1)
2023 (1)
Funding
Current Stage
Growth StageTotal Funding
$226.6MKey Investors
Venrock Healthcare Capital PartnersRedmile GroupVersant Ventures
2024-05-13Series C· $106.6M
2021-09-09Series B· $70M
2020-06-09Series A· $50M
Leadership Team
Aetna Wun Trombley
Chief Executive Officer
Recent News
2025-04-02
2025-04-02
2025-02-12
Company data provided by crunchbase