Research Associate II, Downstream Process Development jobs in United States
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Atsena Therapeutics · 4 days ago

Research Associate II, Downstream Process Development

positionDurham, NC
timeFull-time
remoteOnsite
seniorityEntry, Mid Level
date2+ years exp

Atsena Therapeutics is a clinical-stage gene therapy company focused on treating inherited retinal diseases. They are seeking a motivated Research Associate II to join their CMC – Process Development team, responsible for vector purification and optimization of downstream purification methods.

BiotechnologyHealth CareTherapeutics

Responsibilities

Perform laboratory techniques including preparative chromatography, depth filtration, tangential flow filtration, and ultracentrifugation
Follow established procedures to purify rAAV vectors
Prepare, execute, and analyze study plans to characterize and optimize downstream unit operations with direction from the process development team
Properly document (accurate and up to date) all lab work through an electronic lab notebook (ELN) system
Prepare buffers and other reagents as needed for experiments
Sample testing and data analysis
Comply with standard laboratory practices and company policies, including documentation and biosafety policies
Contribute to the overall mission and culture of Atsena Therapeutics

Qualification

FPLC purificationProcess Development experienceELN software usageCGMP knowledgeStatistical software proficiencyExcel proficiency

Required

Bachelor's degree and a minimum of 2 to 4 years of related experience; or an advanced degree without experience
Prior experience performing FPLC purification of biologics
Prior experience in a Process Development laboratory
Use of an ELN and relevant lab equipment software (Unicorn, ChromLab, etc.)
Proficiency in Excel and other data-centric software

Preferred

Knowledge of cGMPs, USP, ICH, and other guidance documents controlling Process Development activities
Basic understanding of statistical analyses of large datasets, including use of statistical software such as Prism, JMP, or Design Exper.t

Company

Atsena Therapeutics

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Atsena Therapeutics is a clinical-stage gene therapy company that develops novel treatments for inherited forms of blindness.
dateFounded in 2019
location
Durham, North Carolina, USA
people-size11-50 employees
web-link
https://atsenatx.com

Funding

Current Stage
Growth Stage
Total Funding
$237.62M
Key Investors
Bain Capital Life SciencesSofinnova Investments
2025-04-02Series C· $150M
2023-10-02Series Unknown· $24.47M
2020-12-16Series A· $55M

Leadership Team

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Kenji Fujita
Chief Medical Officer
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Recent News

PR Newswire
Genezen and Atsena Therapeutics Announce Strategic Commercial Manufacturing Partnership
2026-01-20
GlobeNewswire
Atsena Completes Dosing in Part B of the Phase I/II/III LIGHTHOUSE Trial Evaluating ATSN-201 to Treat X-linked Retinoschisis and Announces Plans for Initiation of Pivotal Part C Cohort
2026-01-09
GlobeNewswire
Atsena Therapeutics Appoints McDavid Stilwell as Chief Financial Officer
2026-01-06
Company data provided by crunchbase