Foresite Labs · 2 days ago
Sr Staff Engineer, R&D, Mechanical Engineer
San Diego
Full-time
Onsite
Senior Level, Lead/Staff
10+ years expForesite Labs is seeking a Sr Staff Mechanical Engineer to drive the design of an innovative automation system for precision handling and processing of custom parts. The role involves defining requirements, designing electromechanical assemblies, and collaborating with cross-functional teams to ensure system performance and reliability.
BiopharmaBiotechnologyHealth CareMedical
Responsibilities
Define requirements, specifications, tolerance stacks, and error budgets for mechanical subsystems
Conduct trade studies to optimize architecture for performance, manufacturability, cost, and reliability
Own the mechanical system architecture for part processing and precision fluid management modules
Design, develop, and validate complex, high-performance electromechanical assemblies for:
Part transfer and precision positioning
Thermal control and temperature uniformity
Fluid storage and precision dispense
Controlled environmental systems (temperature, humidity, air purity)
Develop metrology solutions for system monitoring, including:
Machine vision for position and alignment measurement
Optical or imaging-based fluid contamination detection
Dynamic spatial temperature measurement and calibration
Select and integrate key components such as motors, bearings, encoders, drives, pneumatics, pumps, valves, sensors, seals, heaters, and thermoelectrics
Collaborate closely with systems, electrical, and software engineers to align mechanical and control architectures
Partner with assay scientists to ensure mechanical designs meet biological and chemical requirements
Work with operations, manufacturing, and supply chain to ensure scalability, cost-efficiency, and high-quality builds
Lead prototype builds and iterative design improvements based on empirical test results
Define and execute mechanical and system-level verification and validation plans
Analyze performance data and reliability metrics to drive continuous improvement
Qualification
Required
B.S. or M.S. in Mechanical Engineering or related field
10–15+ years of experience designing precision electromechanical or fluidic systems for production instruments or automation platforms
Proven ownership of complex systems from concept through product launch
Expert in 3D CAD (SolidWorks) with strong proficiency in GD&T and detailed mechanical drawings
Deep expertise in machine design and precision motion systems
Strong analytical and modeling skills — mechanical, thermal, and system-level
Preferred
Experience in bioinstrumentation, analytical devices, or medical instruments
Working knowledge of embedded controls, sensors, and mechatronic integration
Experience mentoring other engineers and influencing design culture
Company
Foresite Labs
Foresite Labs is a biotechnology company. It is a sub-organization of Foresite Capital.
11-50 employees
H1B Sponsorship
Foresite Labs has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (2)
2022 (1)
Funding
Current Stage
Early StageLeadership Team
Alex Blocker
CTO and Chief Data Scientist
Uplaksh Kumar
COO Foresite Labs and Venture Partner Foresite Capital
Recent News
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2026-01-02
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