Washington University in St. Louis · 14 hours ago
Senior Scientist (Genome Engineering) - Genetics
St Louis, MO
Full-time
Onsite
Mid, Senior Level
$63K/yr - $115K/yr
3+ years expWashington University in St. Louis is seeking a Senior Scientist in the Cremins Lab to oversee and implement research projects focused on genome engineering and cell biology. The role involves leading experiments, mentoring junior scientists, and collaborating on high-quality publications while maintaining lab standards and training protocols.
E-LearningEBooksEducationHigher Education
Responsibilities
Collaborates on designing, conducting and reporting of research projects
Responsible for deliverables of the Cremins lab genome engineering subTeam – including, but not limited to, conceptual selection of experimental strategies, protocol development, experimental design, validation, and training of other lab members in key bleeding edge experimental cell and molecular biology assays, including degrons/dTAG systems engineered in humans iPSCs, Cas13 RNA editing, dCas9 based CRISPRi, and CRISPRa, and other new cutting edge broadly relevant genome engineering technologies
Builds strong expertise in training in human iPSC differentiation to organoids and monolayer neurons as well as pilots experiments to facilitate neural aging in the lab
Leads multiple papers and major research papers at the center of the laboratories larger goals. Designs, conducts, assists and oversees experiments and original research in the area of neuronal genome regulation with a focus on elucidating structure-function relationships across scales of nucleus, synapses, circuits
Assists PI with NIH required data portal approvals, Grant and University-related paperwork, yearly RRPR reports for every one of the lab’s grants - including coordinating with the subTeam members to get the content assembled
Edits and gives feedback on postdoc and student proposal, grant submission, and manuscript drafts
Collaborates fluidly with computational experts to conduct efficient analyses leading to discovery in mammalian neuron genome structure-function data. In parallel, trains to achieve mastery and excellence in running code written by other members of the lab to analyze genomic and imaging data, for example calling DMLs in methylation data, calling compartments, TADs, subTADs, loops in Hi-C/Micro-C data, or peak calling of Cut&Run and Cut&Tag data
Mentors Junior trainees in scientific endeavors under the purview of the SRI’s expertise and trains new lab members on genome engineering and cellular differentiation
Oversees and writes established SOPs for new and existing molecular sequencing technologies – genome engineering, new and existing computational algorithms – iPSC differentiation to neurons, organoids, and assembloids
Complies with established safety procedures and maintains required documentation on laboratory and specimen conditions (maintaining lab freezer maps and plasmid and antibody maps and reagent storage with excellence to keep a 25 person lab organized with high quality infrastructure)
Performs other duties as assigned
Qualification
Required
PhD or Terminal Degree or Combination of Education and Experience May Substitute for Minimum Education
Postdoctoral (3 Years)
Strong background in culturing induced pluripotent stem cells (iPSCs); differentiation of pluripotent cells into neuronal lineages; genome engineering using CRISPR/Cas9; molecular biology and biochemistry laboratory techniques (e.g., molecular cloning); cell biology approaches (e.g., immunofluorescence, RNA/DNA fluorescence in situ hybridization); routine chromatin techniques and sequencing-based technologies (e.g., RNA-seq, ATAC-seq, CUT&Tag/CUT&RUN; Hi-C)
Experience in mentoring and supervising students and trainees
Ability to work in a laboratory environment with potential exposure to biological, chemical and radioactive hazards
Must be physically able to wear protective equipment and to provide standard care to research animals
Preferred
PhD in cell biology, genome engineering/biotechnology, or neuroscience
Excellent communication and interpersonal skills, independent thinking, and a desire to work in a complex and high-energy environment with honor and respect shown to all lab members across rank and the PI
Experience in CRISPR and other forms of genome engineering
Experience in some combinations of human iPSC culture, brain organoids, neuron characterization, computational biology, or in vivo AAV or lentivirus injections
Some experience with the Python/R programming language, Linux environment, and cluster computing
Excellent organizational and time management skills
Ability to work with a multi-disciplinary team
Benefits
Up to 22 days of vacation, 10 recognized holidays, and sick time.
Competitive health insurance packages with priority appointments and lower copays/coinsurance.
Take advantage of our free Metro transit U-Pass for eligible employees.
WashU provides eligible employees with a defined contribution (403(b)) Retirement Savings Plan, which combines employee contributions and university contributions starting at 7%.
Wellness challenges, annual health screenings, mental health resources, mindfulness programs and courses, employee assistance program (EAP), financial resources, access to dietitians, and more!
We offer 4 weeks of caregiver leave to bond with your new child.
Family care resources are also available for your continued childcare needs.
Need adult care? We’ve got you covered.
WashU covers the cost of tuition for you and your family, including dependent undergraduate-level college tuition up to 100% at WashU and 40% elsewhere after seven years with us.
Company
Washington University in St. Louis
Washington University’s mission is to discover and disseminate knowledge, and protect the freedom of inquiry through research and teaching.
10001+ employees
H1B Sponsorship
Washington University in St. Louis has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
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Trends of Total Sponsorships
2025 (22)
2024 (34)
2023 (39)
2022 (17)
2021 (7)
2020 (20)
Funding
Current Stage
Late StageTotal Funding
$24.6MKey Investors
National Institute of Allergy and Infectious DiseasesAmerican Academy of Orthopaedic SurgeonsJim McKelvey
2024-09-13Grant
2023-12-01Grant· $0M
2019-01-31Grant
Leadership Team
Jessie Minton
Vice Chancellor for Technology and Chief Information Officer
Keisha Mabry
Entrepreneur in Residence
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