General Proximity · 1 day ago
Scientist/Sr. Scientist, Functional Genomics
San Francisco, CA
Full-time
Onsite
Senior LevelGeneral Proximity is a seed-stage startup developing the next generation of induced-proximity medicines. They are seeking a first-rate functional genomics expert to be a founding member of their Platform/Bioengineering Team, responsible for developing core drug discovery technology and generating novel therapeutics.
Biotechnology
Responsibilities
Designing and building pooled and arrayed CRISPR or ORFeome libraries for high-throughput screening
Conducting functional genomics and phenotypic screens using lentiviral systems, FACS, and reporter-based assays
Analyzing next-generation sequencing data from pooled screens
Generating and maintaining stable or inducible cell lines for screening and validation studies
Optimizing viral vector production, transduction, and titration protocols
Collaborating across disciplines to refine screening assays, troubleshoot workflows, and interpret results
Qualification
Required
PhD in Molecular Biology, Genetics, Biochemistry, or related field
Deep understanding of small-molecule drug discovery and its relationship to human disease
Demonstrable experience building and validating functional genomics platforms
Strong problem-solving skills and the ability to work independently as well as part of a team
Top-notch written and oral communication skills
Strong experience with genome editing and engineering, particularly CRISPR-based systems, vector design, and cell line engineering
Developing and executing pooled phenotypic and functional genomics screening platforms, from library design to hit validation
Designing and building pooled and arrayed CRISPR or ORFeome libraries for high-throughput screening
Molecular cloning (Gibson, Gateway, PCR) and automation tools for high-throughput assays
Next-generation sequencing (library prep through data analysis)
Data analysis, bioinformatics, and visualization (R, Python, MATLAB)
Multiple gene editing techniques (knockout, HDR knock-in, prime or base editing)
Gene editing in hard to culture cells and Lonza nucleofection
Preferred
Industry experience is desirable, but the ability to work hard and learn fast is more important to us
Managing a team of exceptional scientists and research associates
Target/indication selection
Pre-clinical and IND-enabling studies
Animal models of cancer (GEMM, orthotopic, xenograft models)
Managing CROs for in vivo studies
Grant writing
Familiarity with PROTACs, IPM, or induced-proximity drug discovery
Experience with protein–protein interaction assays (BRET, BioID/APEX, AlphaScreen)
Experience with single-cell RNA sequencing
Experience with bioinformatics and building workflow pipelines
Experience managing others, including CROs
Prior experience on teams that have successfully advanced research to the clinic
Benefits
Strong equity incentives.
Top tier medical, dental, and vision coverage + One Medical membership.
401(k) retirement plans.
Education and health/fitness incentive programs.
Meditation retreats—do a ten-day Vipassana retreat without counting towards vacation days.
Reading budget! We will buy you books.
Company
General Proximity
We are hiring for multiple roles; join us on our journey. Visit our website at https://www.generalproximity.bio.
Founded in 2019
11-50 employees
H1B Sponsorship
General Proximity has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (1)
2021 (2)
Funding
Current Stage
Early StageTotal Funding
unknown2022-01-01Seed
2020-03-01Pre Seed
Leadership Team
Armand Cognetta
Founder/CEO
Recent News
Google Patent
2025-02-16
Company data provided by crunchbase