General Proximity · 5 hours ago
Principal Scientist, Cancer Biology
San Francisco, CA
Full-time
Onsite
Senior Level, Lead/Staff
5+ years expGeneral Proximity is a seed-stage startup developing the next generation of induced-proximity medicines. They are seeking an experienced cancer biologist to lead their Biology Team and collaborate with the Platform Team in advancing their drug discovery technology.
Biotechnology
Responsibilities
Help lead and manage the Biology Team
Work closely with the Platform Team in the development of core drug discovery technology
Phenotypic assay development
Establish pre-clinical •in vitro/in vivo• studies
Perform mechanistic studies on lead drug molecules
Spearhead forays into new oncology indications
Grant writing
Qualification
Required
PhD in Cancer Biology, Cell Biology, or related field
5-7+ years of industry experience
Deep understanding of small-molecule drug discovery and its relationship to human disease
Exceptional leadership, interpersonal, and communication skills, with a track record of managing high-performing, multidisciplinary teams
Strong experience with cellular and molecular biology, including cancer cell line work and associated assays, stable cell line generation (lentiviral and CRISPR-based systems), co-IP/pull-down assays, RNA-seq, global proteomics, flow cytometry, plasmid design/cloning etc
Pre-clinical characterization and mechanistic elucidation of small-molecule drug candidates
Mechanistic studies of cancer cell signaling and PTM analysis
Phenotypic assay development for cancer drug discovery (low to high throughput)
Small molecule drug development campaigns (hit discovery, hit validation, dose-response studies, SAR and MOA studies)
Proficiency in managing a team of exceptional scientists and research associates
Target/indication selection
Animal models of cancer (GEMM, orthotopic, xenograft models), in vivo study design, and PK/PD interpretation
Managing CROs for in vitro and in vivo studies
Grant writing
Preferred
Experience navigating IND-enabling studies and working on teams that have successfully advanced research to the clinic
Experience working at the interface of cancer biology and chemistry
Familiarity or experience with PROTAC/next-gen IPM technologies
Experience with PPI techniques (e.g., BRET, APEX/BioID, AlphaScreen etc.)
Benefits
Strong equity incentives.
Top tier medical, dental, and vision coverage + One Medical membership.
401(k) retirement plans.
Education and health/fitness incentive programs.
Meditation retreats—do a ten-day Vipassana retreat without counting towards vacation days.
Reading budget! We will buy you books.
Company
General Proximity
We are hiring for multiple roles; join us on our journey. Visit our website at https://www.generalproximity.bio.
11-50 employees
H1B Sponsorship
General Proximity has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (1)
2021 (2)
Funding
Current Stage
Early StageTotal Funding
unknown2022-01-01Seed
2020-03-01Pre Seed
Leadership Team
Armand Cognetta
Founder/CEO
Recent News
Google Patent
2025-02-16
Company data provided by crunchbase