Glyphic Biotechnologies · 18 hours ago
Staff/Senior Scientist, Assay Development
Berkeley, CA
Full-time
Onsite
Senior Level
$123K/yr - $188K/yr
4+ years expGlyphic Biotechnologies is developing a revolutionary protein sequencing platform aimed at transforming life science discovery. They are seeking an experienced Assay Development Scientist to design and perform experiments that enhance the accuracy and scalability of their single-molecule protein sequencing processes.
BiotechnologyHealth CareLife Science
Responsibilities
Design, plan, and execute experiments to improve the efficiency, accuracy, and scalability of Glyphic's protein sequencing by expansion (ProSE) process
Propose, design, and test novel analytical approaches to optimize and build predictive understanding of critical components of the ProSE sequencing process including sample preparation, molecular expansion chemistry, automation, and the integration of these components into a robust end-to-end assay
Proactively identify, communicate, and help address experimental risks or resource gaps, such as reagent supply or instrument issues
Collaborate with scientists on the Assay Development team to ensure successful delivery of team goals and prioritize experiments accordingly
Collaborate with scientists in Chemistry, Bioinformatics, Process Development, and Engineering teams to assist and contribute to cross-functional projects
Collect, manage, and analyze data from molecular biology and protein sequencing experiments
Keep a detailed electronic lab notebook on Confluence
Communicate and present results in a timely manner
Qualification
Required
Post-graduate experience in molecular biology, biochemistry, chemistry or related fields, including a: BS/MS/PhD with 10+/8+/6+ years (for Staff Scientist) or BS/MS/PhD with 8+/6+/4+ years (for Senior Scientist)
Experience designing, developing and troubleshooting protocols for highly sensitive molecular assays (PCR-free sequencing, single cell assays, NULISA) with evidence of ownership and innovation
Comprehensive understanding of molecular biology tools used for high sensitivity applications including ligation, polymerase extension and repair, qPCR, NGS barcoding and library preparation, capillary electrophoresis, and surface capture of nucleic acids and peptides enabling root-cause diagnosis and assay optimization
Strong foundation in nucleic acid and peptide biochemistry including the ability to identify common sources of biochemical damage (such as oxidation, depurination, hydrolysis) and methods to avoid or mitigate these effects
Detail-oriented, organized, and able to keep accurate lab records
Strong written and verbal communication skills
Ability to work independently and as a team member
Motivated, enthusiastic, and proactive individual
Preferred
Experience with chemical functionalization of biomolecules or surfaces (e.g. EDC, NHS, Click)
Experience with data analysis using GraphPad Prism, Excel, and/or similar programs
Experience with bead-based automation on instruments such as KingFisher or Hamilton
Familiarity with HPLC for biomolecule purification and validation is a plus
Familiarity with emerging trends and techniques in proteomic measurements is a plus
Benefits
Employee Stock Option Plan
100% Health Plan Coverage for Employees & Dependents (Medical, Dental, & Vision)
Employer Retirement Contributions to 401(k)
Generous Paid Time Off
Paid Maternity and Paternity Leave
Health & Wellbeing Program
Office Snacks and Beverages
Regular Team Bonding Activities
Company
Glyphic Biotechnologies
Glyphic Biotechnologies is a biotechnology company that develops a protein sequencing platform.
11-50 employees
Funding
Current Stage
Early StageTotal Funding
$45.78MKey Investors
FoundersX VenturesLongeVCNational Institutes of Health
2025-09-26Series A· $38M
2024-11-25Seed
2024-01-25Seed
Leadership Team
Joshua Yang
Co-Founder and CEO
Daniel Estandian
CTO and Co-Founder
Recent News
Google Patent
2025-05-04
2025-05-04
2025-02-08
Company data provided by crunchbase