Insmed Incorporated · 4 hours ago
Scientist II, Analytical Development
San Diego, CA
Full-time
Onsite
Mid, Senior Level
$127K/yr - $166K/yr
3+ years expInsmed Incorporated is a global biopharmaceutical company dedicated to transforming the lives of patients with serious and rare diseases. They are seeking a Scientist II on the Analytical Development team to contribute to the analytical procedure development and characterization of gene therapies, executing qualification and validation protocols, and supporting product release and characterization.
BiotechnologyMedicalPharmaceutical
Responsibilities
Develop, improve, implement, transfer and co-validate robust vector genome titer assays with a receiving laboratory (QC internal/external)
Develop NGS sample preparation methods and operate both short read (Element) and long read (PacBio) NGS instruments to characterize AAV drug products, cell lines, and other R&D and CMC samples
Serve as a subject-matter-expert for vg titer, NGS assays and data interpretation
Execute protocols to qualify/validate vg titer assays and characterize AAV drug products and potency assay cell lines
Write and review methods, protocols, reports and other product development documents to support filings (INDs/BLAs) and regulatory interactions (briefing books, etc). Will act as a SME during interactions with health authorities as needed
Define and implement state-of-the art PCR and NGS sequencing technologies for characterizing all facets of our drug products
Design, execute and troubleshoot Next-Generation Sequencing (NGS) assays including nucleic acid (DNA/RNA) purification and library preparation for various sequencing applications including Whole- Genome Sequencing (WGS), Whole-Exome Sequencing (WES), RNA-sequencing, target-enrichment, amplicon sequencing and custom workflows
Work with the bioinformatics team to develop and improve tools and pipelines
Operate, maintain, and troubleshoot short read (Element) and long read (PacBio) sequencing platforms
Maintain accurate, detailed, and timely records of analytical procedure development, experimental data, and data analysis utilizing an electronic lab notebook
Perform data review to ensure accuracy, completeness, and validity
Participate in cross-disciplinary mentoring and training of associate scientists
Present scientific results to the larger Insmed research and technical operations groups, and external scientific community, as needed
Qualification
Required
Bachelor's degree in Molecular Biology, Biochemistry, or a related field with 5+ years of relevant scientific or industry experience; or Master's degree with 3+ years; or PhD with 1+ year of experience
Strong experience with nucleic acid sample preparation, primer/probe design, qPCR/ddPCR, and NGS
Experience developing, optimizing, and troubleshooting short- and long-read sequencing methods
Demonstrated success in method development, including experimental design, execution, and evaluation
Hands-on experience with routine protein characterization techniques such as spectroscopy, SDS-PAGE, western blot, ELISA, and capillary electrophoresis
Experience using JMP or equivalent statistical software for data analysis, assay control charts, and assay acceptance criteria
Excellent written and verbal communication skills
Highly organized with strong attention to detail, clarity, accuracy, and conciseness
Strong analytical and problem-solving skills
Ability to thrive in a dynamic work environment and a demonstrated commitment to diversity of individuals and ideas
Preferred
Familiarity with commercial bioinformatics pipeline interfaces (e.g., GeneData)
Experience in an FDA-regulated, pharmaceutical GMP testing environment
Benefits
Comprehensive medical, dental, and vision coverage and mental health support, annual wellbeing reimbursement, and access to our Employee Assistance Program (EAP)
Generous paid time off policies, fertility and family-forming benefits, caregiver support, and flexible work schedules with purposeful in-person collaboration
401(k) plan with a competitive company match, annual equity awards, and participation in our Employee Stock Purchase Plan (ESPP), and company-paid life and disability insurance
Company Learning Institute providing access to LinkedIn Learning, skill building workshops, leadership programs, mentorship connections, and networking opportunities
Employee resource groups, service and recognition programs, and meaningful opportunities to connect, volunteer, and give back
Company
Insmed Incorporated
Insmed is a people-first global biopharmaceutical company striving to deliver first- and best-in-class therapies to transform the lives of patients facing serious diseases.
1001-5000 employees
H1B Sponsorship
Insmed Incorporated has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (20)
2024 (6)
2023 (14)
2022 (8)
2021 (1)
2020 (5)
Funding
Current Stage
Public CompanyTotal Funding
$4.56BKey Investors
CureDuchenne Ventures
2025-06-11Post Ipo Equity· $750M
2024-05-30Post Ipo Equity· $650M
2023-05-08Post Ipo Equity· $0.5M
Leadership Team
Will Lewis
Chairman and Chief Executive officer
Walter R. Perkins
Chief Technology Officer
Recent News
2026-01-13
2026-01-11
Company data provided by crunchbase