Thermo Fisher Scientific · 2 hours ago
Downstream Process Development Engineer, Bioproduction (Plainville, MA)
Milford, MA
Full-time
Onsite
Senior Level
$96K/yr - $127K/yr
5+ years expThermo Fisher Scientific is seeking a Downstream Process Development Engineer to support development, scale-up, and customer enablement of downstream purification processes using their industry-leading platforms. This role focuses on large-scale chromatography execution, troubleshooting, and technology transfer while collaborating cross-functionally with various teams.
BioinformaticsBiotechnologyCloud Data ServicesConsultingHealth CareLife ScienceManagement Information SystemsOffice SuppliesPrecision Medicine
Responsibilities
Develop and execute downstream purification processes across capture, intermediate, and polishing steps
Perform hands-on large-scale protein purification, including operation of chromatography columns 30 cm to 60 cm ID
Pack, qualify, and troubleshoot large-scale chromatography columns, ensuring consistent performance across cycles
Diagnose and resolve pressure, flow distribution, and resin-related issues, including column fouling, pressure excursions, and yield losses
Make real-time process adjustments during chromatography runs based on system trends and performance data
Operate and optimize chromatography skids (single-use and/or stainless steel), including systems controlled via DeltaV
Review process trends, alarms, and historian data to drive process understanding and improvement
Generate high-quality technical data demonstrating robustness, scalability, and reproducibility
Support PD → pilot → manufacturing scale transitions and participate in customer or internal tech transfer discussions
Lead hands-on customer training, demonstrations, and technical workshops
Collaborate cross-functionally with R&D, automation, manufacturing, and commercial teams
Qualification
Required
B.S. in Chemical Engineering, Biochemistry, Biotechnology, or related field with 5+ years of relevant experience
M.S. with 3+ years of relevant experience
Ph.D. with relevant industry experience
Hands-on experience with protein purification using chromatography, including capture, intermediate, and polishing steps
Direct experience operating large-scale chromatography columns (≥30 cm ID)
Experience packing and qualifying chromatography columns in development or pilot-scale environments
Strong ability to diagnose chromatography performance issues, including pressure, flow, and resin behavior
Solid mechanical and fluid-flow intuition for packed-bed chromatography
Experience operating downstream single-use purification systems
Demonstrated end-to-end ownership of unit operations, with accountability for execution and outcomes
Strong planning, execution, and technical documentation skills
Preferred
Experience operating chromatography columns 45–60 cm ID at pilot or manufacturing scale
Hands-on experience with resin lifetime studies, reuse strategies, and column performance trending across multiple cycles
Understanding of resin selection tradeoffs (binding capacity, pressure limitations, fouling risk)
Knowledge of cleaning, sanitization, and storage practices for chromatography resins and columns
Experience operating chromatography skids using DeltaV, including navigation of batch phases and recipe logic
Ability to collaborate with automation engineers on phase logic optimization and troubleshooting
Familiarity with electronic batch records (EBR) or MES interfaces
Understanding of scale-dependent risks, including flow distribution, pressure scaling, and residence time effects
Experience translating small-scale learnings into robust operating ranges for pilot or manufacturing scale
Experience supporting customer-facing troubleshooting, training, or technology transfer activities
Demonstrated proactive identification of process risks and continuous improvement opportunities
Benefits
A choice of national medical and dental plans, and a national vision plan, including health incentive programs
Employee assistance and family support programs, including commuter benefits and tuition reimbursement
At least 120 hours paid time off (PTO), 10 paid holidays annually, paid parental leave (3 weeks for bonding and 8 weeks for caregiver leave), accident and life insurance, and short- and long-term disability in accordance with company policy
Retirement and savings programs, such as our competitive 401(k) U.S. retirement savings plan
Employees’ Stock Purchase Plan (ESPP) offers eligible colleagues the opportunity to purchase company stock at a discount
Company
Thermo Fisher Scientific
Thermo Fisher Scientific is a biotechnology and laboratory equipment company that provides a wide range of scientific products and services.
10001+ employees
H1B Sponsorship
Thermo Fisher Scientific has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
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Trends of Total Sponsorships
2025 (272)
2024 (224)
2023 (233)
2022 (342)
2021 (315)
2020 (227)
Funding
Current Stage
Public CompanyTotal Funding
$15.97BKey Investors
National Grid
2025-11-24Post Ipo Debt· $2.42B
2025-09-30Post Ipo Debt· $2.5B
2023-08-07Post Ipo Debt· $2.95B
Leadership Team
Stephen Williamson
Senior Vice President and Chief Financial Officer
Michel Lagarde
Chief Operating Officer
Recent News
CB Insights
2026-01-23
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