Roche · 5 hours ago
Senior Principal Software Engineer
Pleasanton, CA
Full-time
Onsite
Senior Level, Lead/Staff
$189K/yr - $270K/yr
8+ years expRoche is a global healthcare company dedicated to advancing science and ensuring access to healthcare. They are seeking a Senior Principal Software Engineer specializing in Next Generation Sequencing Bioinformatics to design, develop, and optimize algorithms for genomic data analysis.
BiotechnologyHealth CareHealth DiagnosticsOncologyPharmaceuticalPrecision Medicine
Responsibilities
Algorithm Development: Design and implement high-performance algorithms for NGS data analysis, including variant calling, quality control, and data preprocessing
Optimization: Continuously refine and optimize bioinformatics solutions for handling large-scale genomic datasets with improved efficiency and performance
Collaboration: Partner with biologists, data scientists, and engineers to meet the unique challenges of NGS diagnostics and research workflows
Software Integration: Seamlessly incorporate bioinformatics tools into Roche's software ecosystem, ensuring compatibility and robustness
Quality Assurance: Maintain the integrity of analytical results by crafting rigorous test suites and working alongside QA teams
Innovation and Leadership: Stay at the forefront of NGS and bioinformatics trends while mentoring junior engineers and driving innovation within the company
Qualification
Required
You hold a Bachelor's or higher degree in Computer Science, Bioinformatics, Computational Biology, or a related field
You have at least 8-10 years of proven experience in developing high quality software and algorithms for NGS data analysis
You have strong proficiency in programming languages such as C++ and Python
You have a track record of proficiency in relevant bioinformatics tools and libraries
Demonstrated progression in experience with parallel computing, optimization, and performance tuning
You have strong problem-solving skills and attention to detail
You have excellent communication and teamwork skills
Preferred
Experience working in a regulated environment (e.g., FDA, CLIA)
Experience with GPU development and optimization
Company
Roche
Roche is a pharmaceutical and diagnostics company that offers medicines and diagnostic tests for various medical conditions and diseases.
10001+ employees
H1B Sponsorship
Roche has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (12)
2024 (9)
2023 (6)
2022 (2)
2021 (2)
Funding
Current Stage
Public CompanyTotal Funding
$7.79BKey Investors
SoftBankSCALE AINovartis
2021-08-04Post Ipo Equity· $5B
2020-12-07IPO
2020-05-06Post Ipo Equity· $0.5M
Leadership Team
Alan Hippe
Member of the Executive Board - Group CFO
Christine Bakan
Global Head and Group Vice President, Computational Science and Informatics R&D
Recent News
2026-01-25
2026-01-23
2026-01-22
Company data provided by crunchbase