Axle · 17 hours ago
Biologist
Rockville, MD
Full-time
Onsite
Mid, Senior Level
$65K/yr - $75K/yr
5+ years expAxle is a bioscience and information technology company that offers advancements in translational research and biomedical informatics. They are seeking a Biologist to provide services in support of the Vaccine Research Center, focusing on developing purification processes and collaborating on mRNA-LNP projects.
BiotechnologyHealth CareInformation TechnologySoftware
Responsibilities
Develop downstream (purification) processes, under the supervision of a project lead scientist, for recombinant proteins, virus vaccines, and virus-like particles (VLP) that may be used as clinical candidates
Design and execute mRNA-Lipid Nanoparticle (LNP) process development studies for mRNA-lipid nanoparticle encapsulation
Serve as SME with operation and optimization of microfluidic systems, e.g. Precision NanoSystem, Inc Ignite and Blaze, and/or Knauer NanoScaler Impingement Jet Mixers
Develop scale down and scale-up operations to advance tech transfer to manufacturing and/or enable troubleshooting
Screen and optimize tangential flow filtration processes for mRNA-LNP products to generate preclinical materials and drive tech transfer for clinical manufacturing
Design and execute lipid screening studies to evaluate novel lipid components and formulations for use in pre-clinical safety and efficacy studies
Collaborate with analytical and formulation scientist to characterize mRNA-LNP formulations and optimize process flows and sample stability
Perform in vitro transcription reactions to generate mRNA products
Purify research-phase recombinant proteins, virus vaccines and/or virus-like particles in collaboration with other groups or external collaborators
Work within the purification group to design, develop and optimize chromatography and filtration step unit operations to drive process development of clinical trial vaccine candidates and mAb products
Collaborate with project management to ensure mRNA-LNP development milestones and study deliverables are met in a timely manner
Work to prepare necessary materials (buffers, packed columns, etc.) for execution of downstream process activities
Perform technology transfer of processes to VRC Pilot Plant for manufacture of clinical product through document generation and on-site support
Write and review tech transfer documents, technical protocols and reports
Generate supporting documents, as necessary, for IND-filings and other regulatory needs
Analyze and compile data, present at various group/department meetings
Qualification
Required
Bachelor's degree in Bioengineering, Chemical Engineering, Biochemistry, or a related discipline
5-7 yr experience in recombinant protein purification and mRNA-LNP development for GMP clinical-phase products
Demonstrated knowledge of maintaining accurate and detailed records
Must be a team player who can effectively work with members from cross-functional departments
Strong oral and written communication skills
Familiarity with computer software including word processing and data evaluation
All support positions required a minimum of a BS degree; some require a MS, MD, or Ph.D
The education, skills and relevant years of experience required for each support position are consistent with those identified as the minimum requirements for the labor categories specified in the contract
Benefits
100% Medical, Dental & Vision Coverage for Employees
Paid Time Off (Including Holidays)
Employee Referral Bonus
401K Match
Tuition reimbursement and professional development opportunities
Flexible Spending Accounts:
Healthcare (FSA)
Parking Reimbursement Account (PRK)
Dependent Care Assistant Program (DCAP)
Transportation Reimbursement Account (TRN)
Company
Axle
At Axle, we are driven by the mission to accelerate discovery and enhance organizational outcomes by revolutionizing operations with our innovative solutions.
501-1000 employees
H1B Sponsorship
Axle has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (37)
2024 (40)
2023 (61)
2022 (30)
2021 (19)
2020 (38)
Funding
Current Stage
Late StageLeadership Team
Gary Mays
Chief Operating Officer
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