Crownlands · 2 days ago
Computational Biology Intern
San Francisco, CA
Internship
Onsite
Intern
$90K/yr - $90K/yrCrownlands is building a precision neurology discovery platform to understand neurodegenerative and psychiatric disease. They are seeking Computational Biology Interns to work on single-cell analysis and contribute to tooling that enhances reproducibility and scalability within the organization.
Biotechnology
Responsibilities
Cell typing and lineage refinement: Improve depth and accuracy for targeted lineages to unlock new biological and product capabilities
Robust gene programs and networks: Evaluate and harden workflows (program calling, network inference, stability/robustness checks) that generalize across donors and batches
State/factor modeling: Apply latent factor and state methods (e.g., pathway/state scoring, decomposition approaches) and convert outputs into interpretable biology and usable artifacts
Internal analysis and ML tooling: Contribute to pipelines and libraries that increase iteration speed, reproducibility, and auditability
Agent-ready, standardized analysis tools: Build MCP-compatible tools so internal agents can query human curated analysis outputs and return structured synthesis (tables/plots/metrics) consistently
Qualification
Required
Typical background: senior student (undergraduate, master's, or PhD) in CS, Biology, Computational Biology, Genetics, Neuroscience, or a related field
Hands-on single-cell analysis experience (Seurat and/or Scanpy)
Strong R and/or Python, plus practical UNIX competence (environments, CLI workflows, basic debugging)
Demonstrated ability to deliver (e.g., a GitHub repo, publication, preprint, poster, project write-up)
Comfort working in ambiguous problem spaces and driving work to completion
Preferred
Familiarity with neuroscience and/or neurodegenerative disease research
Experience building reusable tooling: packages, pipelines, CI/testing, containers, workflow orchestration, or cloud/HPC
Experience with robustness/stability evaluation across donors/batches (downsampling, perturbation testing, sensitivity analyses)
Benefits
Public transit commute support
Equipment provided
Company
Crownlands
Crownlands develops precision medicines for neurodegenerative and CNS diseases with data and scale.
Founded in 2024
11-50 employees
Funding
Current Stage
Early StageCompany data provided by crunchbase