Structure Therapeutics · 19 hours ago
Director, Clinical Pharmacology and Pharmacometrics
South San Francisco, CA
Contract
Hybrid
Director/Executive
$225K/yr - $290K/yr
7+ years expStructure Therapeutics develops life-changing medicines for patients using advanced structure-based and computational drug discovery technology. The Director, Clinical Pharmacology and Pharmacometrics will work with cross-functional stakeholders to support the discovery and development of pipeline molecules, contributing to translational approaches and leading pharmacometrics deliverables for regulatory submissions.
BiotechnologyHealth CareMedicalPharmaceuticalProduct Research
Responsibilities
Support and help advance model-informed drug development (MIDD) across discovery and development programs
Represent Pharmacometrics on cross-functional teams, providing quantitative input to strategy, dose selection, and trial design; influence decisions through data-driven recommendations
Plan, execute, and document pharmacometrics analyses (PopPK/PKPD/exposure–response), including models, simulations, and reports
Develop and maintain Shiny-based applications to enable data visualization and model-based simulation workflows, with potential integration of AI/ML-enabled features as appropriate
Coordinate and oversee external vendors/consultants and review deliverables for quality and timeliness
Contribute to pharmacometrics elements of regulatory submissions and health authority responses, with guidance from function leadership
Support functional process improvements (e.g., templates, workflows, and modeling infrastructure) and other needs (e.g., due diligence) as assigned
Qualification
Required
Advanced degree (PhD, PharmD, MS) in Engineering, Mathematics, Statistics, Pharmaceutical Sciences, or a related field
7+ years of drug development experience in biotech/pharma (or equivalent combination of industry and relevant consulting experience)
Demonstrated hands-on experience with commonly applied pharmacometric methodologies (e.g., PopPK, PKPD, exposure–response, MBMA/statistical modeling)
Proficiency with pharmacometrics and data analysis tools such as NONMEM, R, and one or more of Monolix, Phoenix/WinNonlin, Matlab, SAS (as appropriate for role)
Experience contributing to clinical pharmacology/pharmacometrics deliverables that support regulatory submissions and/or health authority interactions
Experience with dataset creation and data assembly/review/visualization in support of modeling deliverables
Preferred
Experience applying AI/ML in drug development
Experience supporting small-molecule development
Cardiometabolic experience (e.g., T2D/obesity)
PBPK experience using platforms such as Simcyp and/or GastroPlus
Benefits
Annual performance incentive bonus
New hire equity
Ongoing performance-based equity
Medical, dental, and vision insurance
401k match
Unlimited PTO
Paid holidays including winter shutdown
Company
Structure Therapeutics
Structure Therapeutics specializes in the discovery and development of drugs against a type of targets called GPCR.
51-200 employees
Funding
Current Stage
Public CompanyTotal Funding
$1.77BKey Investors
Biotechnology Value FundQiming Venture Partners
2025-12-09Post Ipo Equity· $747.5M
2024-06-05Post Ipo Equity· $547.4M
2023-09-29Post Ipo Equity· $300M
Leadership Team
Raymond Stevens
Chief Executive Officer
Jun Yoon
Chief Financial Officer
Recent News
Benzinga.com
2026-01-23
2026-01-16
The Motley Fool
2026-01-12
Company data provided by crunchbase