TCG Labs Soleil · 9 hours ago
Associate Scientist / Scientist I, Protein Sciences, Biophysical Assays, SPR
South San Francisco, CA
Full-time
Onsite
Mid, Senior Level
$91K/yr - $175K/yr
5+ years expTCG Labs-Soleil is building a team of scientists driven to push the boundaries of therapeutic discovery. They are seeking a motivated Associate Scientist/Scientist I to join their Protein Sciences team and contribute to the advancement of a diverse biologics pipeline through hands-on design and execution of assays.
Biotechnology
Responsibilities
Design, execute, and analyze high- to medium-throughput biosensor-based interaction assays (SPR, BLI), including antibody screening, epitope binning, and binding kinetics
Develop, optimize, and implement biosensor assay methods to support biologics discovery and development efforts, spanning early discovery through lead optimization and development candidate selection (e.g. monoclonal antibodies, bispecifics, multispecifics, fusion proteins, etc.)
Generate high-quality, reproducible data in a timely manner and collaborate with cross-functional teams to interpret results and support program-level decision-making
Troubleshoot assay-related technical challenges and contribute to continuous improvement of assay workflows, data quality, and reliability
Operate and maintain biosensor instrumentation, ensuring optimal performance and adherence to best laboratory practices
Maintain clear, thorough documentation of experimental protocols, results, and data analysis
Communicate scientific findings by presenting experimental results in team meetings and cross-departmental forums, fostering collaboration and enabling data-informed decisions
Qualification
Required
M.S. in Biochemistry, Biophysics, Chemistry, Analytical Chemistry, or related field with 5+ years of relevant experience, or B.S. with 10+ years of relevant experience
Prior experience in pharma, biotech, or startup environments is required; startup experience is strongly preferred
Strong, hands-on experience with SPR and BLI (e.g. Carterra, Biacore, Gator, Octet, or other biosensor platforms)
Solid understanding of binding kinetics, affinity measurement experiments, and data analysis/fitting tools
Demonstrated experience with antibody screening, epitope binning, and binding kinetics assays
Proven ability to troubleshoot technical challenges and adapt quickly in a dynamic research environment
Must demonstrate strong organizational skills with the ability to manage multiple priorities while maintaining high data quality, precision, and attention to every detail
Excellent written and verbal communication skills, with a demonstrated commitment to clear experimental documentation
Collaborative, adaptable, and enthusiastic about working in a fast-paced startup environment
Proven ability to deliver results in a dynamic, highly multitasking research setting
Ability to work effectively both independently and as part of an inclusive, team-oriented environment
Preferred
Experience with small molecule-protein interaction analysis is a plus
Experience or familiarity with automation and liquid handling systems is a plus
Benefits
Medical, Dental, and Vision Insurance
Life Insurance
Short and Long Term Disability
Health Savings Account (HSA)
Flexible Spending Accounts (FSA)
401k plan
PTO
Company
TCG Labs Soleil
At TCG Labs Soleil, we are establishing a pioneering venture-biotech model in collaboration with The Column Group.
11-50 employees
Funding
Current Stage
Early StageLeadership Team
Jin-Long Chen
Managing Partner, TCG Labs | Co-Founder and Chief Executive Officer, Soleil
Harding Luan
VP, Discovery Research and Co-Founder
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2025-07-26
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