Summit Therapeutics, Inc. · 16 hours ago
Director of Protein Engineering
Palo Alto, CA
Full-time
Onsite
Director/Executive
$200K/yr - $250K/yr
10+ years expSummit Therapeutics Inc. is a biopharmaceutical oncology company focused on improving quality of life through innovative therapies. The Director of Protein Engineering will lead and drive therapeutic protein discovery, focusing on the design and optimization of novel therapeutics for cancer treatment.
BiotechnologyHealth CareMedical DeviceTherapeutics
Responsibilities
Drive multiple drug discovery programs concurrently, ensuring efficient progression from conceptual design to the selection of clinical development candidates, meeting aggressive project timelines
Lead the design, development and engineering of novel protein therapeutics, including antibodies and bispecific/multimeric molecules, to enhance function, stability, safety and developability for oncology applications
Utilize molecular engineering approaches driven by AI/ML, novel display technology, directed evolution and structure-guided design, to optimize protein candidates
Perform hands-on protein expression in transient eukaryotic systems (e.g., HEK293, CHO cells) and generate stable expression cell lines
Execute protein purification using various chromatography techniques (affinity, IEX, SEC, etc.) and FPLC/HPLC systems
Conduct comprehensive analytical and functional characterization of engineered proteins using techniques such as SDS-PAGE, ELISA, flow cytometry, SPR/BLI, and endotoxin measurement
Collaborate with cross-functional teams to drive projects from target validation through candidate nomination
Troubleshoot experiments, develop new protocols, and document findings in electronic lab notebooks and technical reports
Present data and research updates effectively at internal meetings and external scientific conferences
Stay current with the latest advancements in protein engineering, cancer biology, and immunotherapy to propose and implement innovative technologies
All other duties as assigned
Qualification
Required
PhD in Biochemistry, Molecular Biology, Chemical Engineering, or a related scientific field (or MS with equivalent industry experience)
A minimum of 10+ years of relevant experience in recombinant protein engineering and expression within an academic or industrial setting
Extensive hands-on experience with molecular biology techniques, including DNA manipulation, cloning, and mutagenesis
Proficiency in protein expression, purification, and characterization
Strong problem-solving abilities and a proactive, hands-on attitude
Excellent oral and written communication skills, with meticulous attention to detail in documentation and record-keeping
Ability to work both independently/team leader and collaboratively within a fast-paced, multidisciplinary team environment
Preferred
Familiarity with computational modeling tools and bioinformatics software (e.g., PyMOL, Geneious) for physical chemical characterization for protein design is desirable
Experience with antibody-drug conjugates (ADCs), T-cell engagers, or other immune-based therapeutic modalities is a plus
Benefits
Bonus
Stock
Benefits
Other applicable variable compensation
Company
Summit Therapeutics, Inc.
Summit Mission Statement: To build a viable, long-lasting health care organization that assumes full responsibility for designing, developing, trial execution and enrollment, regulatory submission and approval, as well as successful commercialization of patient, physician, caregiver, and societal-friendly medicinal therapy intended to: improve quality of life, increase potential duration of life, and resolve serious medical healthcare needs.
201-500 employees
H1B Sponsorship
Summit Therapeutics, Inc. has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (3)
2024 (6)
2023 (1)
Funding
Current Stage
Public CompanyTotal Funding
$1.79BKey Investors
CARB-XEurofarmaBiomedical Advanced Research and Development Authority (BARDA)
2025-10-21Post Ipo Equity· $500M
2024-09-11Post Ipo Equity· $235M
2024-06-03Post Ipo Equity· $200M
Leadership Team
Manmeet Soni
Chief Operating Officer and Chief Financial Officer
Recent News
Company data provided by crunchbase