C4 Therapeutics, Inc. · 4 hours ago
Senior Research Scientist, DNA-Encoded Library Screening
Watertown, MA
Full-time
Onsite
Senior Level
$158K/yr - $175K/yr
5+ years expC4 Therapeutics is a clinical-stage biopharmaceutical company dedicated to delivering on the promise of targeted protein degradation science. They are seeking a Senior Scientist to join the DNA Encoded Library Technology team, where the role involves leading laboratory efforts and advancing drug discovery projects.
Health DiagnosticsMedicalTherapeutics
Responsibilities
Lead MonoDAC DEL laboratory efforts to advance drug discovery projects in a multidisciplinary, collaborative project team setting
Provide DEL selection strategy in partnership with Director, DNA Encoded Library Platform and execute plans, interpret and communicate results, and recommend next steps to the project team
Design and execute DEL selections for identification of molecular glues to be developed into degraders
Contribute to intellectual development of next generation DEL technology for targeted protein degradation (TPD)/molecular glue identification
Take ownership of platform performance and data integrity, partnering closely with bioinformatics/computational chemistry on data analysis
Manage the operational and inventory needs of the DEL lab, including specific instrumentation and reagents
Manage CRO interactions as needed
Qualification
Required
A Ph.D. or equivalent in Biology or a related field with a minimum of five years of relevant experience in the biotech/pharma setting; additional experience can compensate for required education
Deep knowledge in DNA Encoded Library Technology with strong expertise in developing and applying DEL selections for ternary complex binders across target classes
Thorough understanding of protein biochemistry and binding kinetics
Familiarity with targeted protein degradation as a therapeutic modality
Demonstrated success in providing high fidelity data to teams to drive downstream program decisions and operational vision to integrate DEL platform into broader Hit ID strategy
Preferred
Experience maintaining DEL specific instrumentation and inventory of all workflow reagents
Solid experience in Next Generation Sequencing (NGS) library prep and sequencing run execution
Company
C4 Therapeutics, Inc.
C4 Therapeutics (C4T) (Nasdaq: CCCC) is a clinical-stage biopharmaceutical company dedicated to delivering on the promise of targeted protein degradation science to create a new generation of medicines that transforms patients’ lives.
51-200 employees
H1B Sponsorship
C4 Therapeutics, Inc. has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (1)
2024 (1)
2023 (1)
2022 (3)
2020 (1)
Funding
Current Stage
Public CompanyTotal Funding
$423.8MKey Investors
RA Capital ManagementBetta PharmaceuticalsPerceptive Advisors
2025-10-16Post Ipo Equity· $125M
2023-05-30Post Ipo Equity· $25M
2022-08-15Post Ipo Equity
Leadership Team
Kendra Adams
Chief Financial Officer
Recent News
BioWorld Financial Watch
2026-01-16
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