Flagship Pioneering · 14 hours ago
Senior / Principal Scientist, Structural Biology
Cambridge, MA USA
Full-time
Onsite
Senior Level, Lead/Staff
$126K/yr - $214K/yr
3+ years expFlagship Pioneering is an organization that creates and builds life sciences companies innovating in health care and sustainability. The Senior/Principal Scientist, Structural Biologist will focus on determining protein-ligand complex structures to enable structure-based drug design and collaborate with project teams on small molecule mechanisms of action.
FinanceFinancial ServicesVenture Capital
Responsibilities
Design and execute structural biology strategy for one or more projects
Oversee construct design, expression and purification of proteins for structure determination
Develop and execute protocols to obtain high quality crystals for X-ray structures
Develop and execute protocols for grid optimization, data collection, and data analysis for structure determination using cryo-EM
Obtain and refine structures of protein-ligand complexes, communicate the results and collaborate with project teams to drive hit-to-lead and lead optimization
Manage CROs for effective delivery of protein expression and structural biology services
Expand our capabilities and serve as a trusted expert in structural biology
Qualification
Required
PhD/MS degree in structural biology, biochemistry, molecular biology, or a related field with at least 3 years of drug discovery experience in an industry setting
In-depth knowledge and hands-on experience in X-ray crystallography and cryo-EM, including crystal optimization, grid preparation, data collection, data processing, structure refinement, and interpretation of protein structures
Experience managing CROs for protein production and structural biology
Excellent collaboration, communication, and organizational skills
Strong desire to learn and implement new methods in protein biochemistry, biophysics, and structural biology
Preferred
Experience with biophysical methods (SPR, DSF, MST) or mass spectrometry (intact MS, peptide mapping, proteomics)
Benefits
Healthcare coverage
Annual incentive program
Retirement benefits
Broad range of other benefits
Company
Flagship Pioneering
Flagship Pioneering is a venture capital firm that invests in life sciences and healthcare companies.
501-1000 employees
H1B Sponsorship
Flagship Pioneering has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (8)
2024 (4)
2023 (4)
2022 (4)
2021 (1)
Funding
Current Stage
Late StageLeadership Team
Noubar Afeyan
Founder and CEO
Chuck Carelli
Chief Financial Officer
Recent News
2026-01-16
2026-01-16
Company data provided by crunchbase