Johnson & Johnson · 4 hours ago
Senior Principal Scientist II, In Silico Biologics
Spring House, Pennsylvania, United States of America
Full-time
Hybrid
Senior Level, Lead/Staff
$137K/yr - $236K/yr
6+ years expJohnson & Johnson is a leader in healthcare innovation, dedicated to developing treatments and finding cures. The Senior Principal Scientist II will lead efforts in antibody design and multifunctional molecule optimization, collaborating with teams to execute strategic initiatives in computational design and AI/ML.
Hospital & Health Care
Responsibilities
Partner closely with Biologics Discovery teams to drive drug discovery projects through application of predictive and AI/ML tools for biologics design and optimization
Mentor junior scientists, fostering their development as expert informatics scientists
Engage in industry consortia and represent J&J and In Silico Discovery in key initiatives
Periodically be tasked with evaluating and making recommendations for the acquisition or building of new technologies. This may include performing Due Diligence on potential partnering/M&A opportunities
Contribute to an inspiring, scientifically rigorous and innovative culture that embraces continuous learning, development and collaboration
Contribute towards efforts to influence J&J's external environment via scientific publications in peer-reviewed journals and participation in external conferences as needed
Qualification
Required
A PhD and a minimum of 6 years of experience in drug discovery and development with industry or related leadership experience
Demonstrated expertise in the field of AI/ML, computation and antibody design & optimization in drug discovery
Strong understanding of pharmaceutical discovery and optimization processes
Hands-on experience with large-scale data curation, aggregation, manipulation, integration, mining and analysis, including structured and unstructured data sources
Preferred
Experience with data visualization tools (e.g. Spotfire, Vortex, Tableau, DataWarrior)
Ability to organize and convey complex data sets in a clear and concise manner to key business partners from diverse backgrounds
Prior experience leading or participating in collaborations with external academic, biotechnology and contract research organizations
Strong publication and/or proven track record of supporting discovery of clinical/pre-clinical candidates
Strong motivation, passion and commitment to science and patients
Benefits
Medical
Dental
Vision
Life insurance
Short- and long-term disability
Business accident insurance
Group legal insurance
Consolidated retirement plan (pension)
Savings plan (401(k))
Vacation – up to 120 hours per calendar year
Sick time - up to 40 hours per calendar year
Holiday pay, including Floating Holidays – up to 13 days per calendar year
Work, Personal and Family Time - up to 40 hours per calendar year
Company
Johnson & Johnson
At Johnson & Johnson, we believe health is everything.
10001+ employees
H1B Sponsorship
Johnson & Johnson has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (48)
2024 (56)
2023 (58)
2022 (59)
2021 (44)
2020 (27)
Funding
Current Stage
Late StageLeadership Team
Alex Gorsky
Former Chairman and CEO, Johnson & Johnson
Joaquin Duato
Chairman of the Board and Chief Executive Officer
Recent News
2025-10-07
2025-10-07
Company data provided by crunchbase