Alnylam Pharmaceuticals · 12 hours ago
Sr. Scientist, Clinical Pharmacology
Cambridge, MA
Full-time
Hybrid
Mid, Senior Level
$132K/yr - $178K/yr
2+ years expAlnylam Pharmaceuticals is the leader in RNAi therapeutics, focused on transforming the lives of people with rare and common diseases. The Senior Scientist, QSP Modeling will develop and apply mechanistic quantitative systems pharmacology models to support drug discovery and development, integrating diverse data sources and collaborating with cross-functional teams.
BiotechnologyHealth CareMedicalPharmaceuticalTherapeutics
Responsibilities
Develop, calibrate, and validate mechanistic QSP models to describe disease biology, drug mechanism of action, and PK/PD relationships
Integrate diverse data sources (in vitro, in vivo, clinical, omics, literature) into QSP modeling frameworks
Perform model-based simulations to support:
+ Target and pathway evaluation
+ Dose and regimen selection
+ Biomarker strategy
+ Translational predictions from preclinical to clinical stages
Collaborate closely with cross-functional teams including Biology, Pharmacology, Clinical Pharmacology, Biomarkers, and Translational Medicine
Document model assumptions, structure, qualification, and limitations according to internal and regulatory standards
Prepare technical reports, presentations, and visualizations to communicate model insights to project teams
Contribute to publications, posters, and internal scientific forums
Maintain awareness of emerging QSP methodologies, tools, and best practices
Qualification
Required
PhD (or equivalent) in Pharmacology, Systems Biology, Bioengineering, Applied Mathematics, Chemical Engineering, or a related quantitative discipline
2–5 years of experience applying QSP or mechanistic modeling in pharmaceutical or biotech settings (or equivalent postdoctoral + industry experience)
Benefits
Comprehensive benefits including medical, dental, and vision coverage
Life and disability insurance
Lifestyle reimbursement program
Flexible spending and health savings accounts
401(k) with a generous company match
Paid time off
Wellness days
Holidays
Two company-wide recharge breaks
Generous family resources and leave
Company
Alnylam Pharmaceuticals
Alnylam Pharmaceuticals is a biopharmaceutical company focused on the discovery, development and commercialization.
1001-5000 employees
H1B Sponsorship
Alnylam Pharmaceuticals has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2022 (18)
2021 (19)
2020 (7)
Funding
Current Stage
Public CompanyTotal Funding
$4.55BKey Investors
Blackstone Life SciencesBlackstone CreditRegeneron
2025-09-09Post Ipo Debt· $661.25M
2022-09-12Post Ipo Debt· $900M
2022-03-04IPO
Leadership Team
Yvonne Greenstreet
Chief Executive Officer
Jeff Poulton
Chief Financial Officer
Recent News
Clinical Trials Arena
2026-01-16
Longevity.Technology
2026-01-14
2026-01-13
Company data provided by crunchbase