Roche · 9 hours ago
Principal Scientist, Lab Head, Metabolism Drug Discovery
South San Francisco
Full-time
Onsite
Senior Level, Lead/Staff
$143K/yr - $266K/yr
4+ years expGenentech is a leading biotechnology company focused on innovative healthcare solutions. They are seeking a Principal Scientist, Lab Head to lead efforts in metabolic disease research, specifically in the cardiometabolic pipeline, including obesity and its comorbidities.
BiotechnologyHealth CareHealth DiagnosticsOncologyPharmaceuticalPrecision Medicine
Responsibilities
Lab focused and biology driven, building and managing a team (approximately 2 direct reports) of expert experimental biologists focused on metabolic disease biology, target and drug discovery. The incumbent will conduct experimental biology, with their team, in support of disease biology, target discovery and validation
Apply expertise of biological pathways of metabolism, appetite regulation, energy homeostasis, nutrient flux and their dysregulation in disease. The incumbent is able to utilize this knowledge to design, run and interpret experiments at the molecular, cellular and organismal level
Establish and leverage experimental models of disease, including models applicable to genetic or drug screening, to more complex models that capture key aspects of human metabolic disease
Serve as biology lead in preclinical metabolism drug discovery programs, guiding the evaluation and development of novel therapeutics for cardiometabolic diseases including obesity and its comorbidities. Drive biology strategy through a practical understanding of drug discovery optimization and screening cascades, and a hands-on understanding of key biology experiments to conduct in support of go/no-go decisions
Interdisciplinary Collaboration: Partner closely with internal teams across departments and disciplines, including Drug Development, Translational Medicine, Computational and Clinical Science , to drive innovative therapeutic strategies, formulate new therapeutic hypotheses and advance transformative medicines
Communicate findings to internal meetings and governance boards, author documents including IND reports, and publish impactful scientific discoveries
Manage day-to-day lab operations, ensure best practices and compliance for ELN and documentation, and oversee external collaborations or outsourcing as needed
Foster a collaborative, high-performance team culture, mentor and motivate team, and provide career development for scientists and research associates
Qualification
Required
PhD, MD, or MD/PhD in Metabolism, Cardiovascular Research, Neuroscience, Endocrinology, Physiology or a related discipline
Minimum 4 years post-Ph.D. of productive postdoctoral training and/or industry experience
Proven track record of driving innovative research in metabolic disease
Strong hands on lab experience in the latest state-of-the-art techniques applied to metabolic disease research
Demonstrated impact through high-quality publications, patents, and/or successful program advancement
Expertise spanning basic and translational research focusing on metabolic disease including obesity, diabetes, cardiovascular disease, renal disease, heart disease, MASH, and related indications
Exceptional leadership potential and a track record of working with multidisciplinary teams, excellent written and verbal communication skills, and a collaborative spirit
Preferred
Experience in human genetics
Application of AI/ML based methodologies to biological research
Hands-on experience with in vivo CVRM models and techniques
Benefits
Relocation benefits are available for this posting.
A discretionary annual bonus may be available based on individual and Company performance.
This position also qualifies for the benefits detailed at the link provided below.
Company
Roche
Roche is a pharmaceutical and diagnostics company that offers medicines and diagnostic tests for various medical conditions and diseases.
10001+ employees
H1B Sponsorship
Roche has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (12)
2024 (9)
2023 (6)
2022 (2)
2021 (2)
Funding
Current Stage
Public CompanyTotal Funding
$7.79BKey Investors
SoftBankSCALE AINovartis
2021-08-04Post Ipo Equity· $5B
2020-12-07IPO
2020-05-06Post Ipo Equity· $0.5M
Leadership Team
Alan Hippe
Member of the Executive Board - Group CFO
Christine Bakan
Global Head and Group Vice President, Computational Science and Informatics R&D
Recent News
2026-01-25
2026-01-23
2026-01-22
Company data provided by crunchbase