Madrigal Pharmaceuticals · 7 hours ago
Director, Nonclinical Research
PA - Conshohocken - Office
Full-time
Onsite
Director/Executive
$216K/yr - $264K/yr
12+ years expMadrigal Pharmaceuticals is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH). The Director will provide scientific and strategic leadership for nonclinical development programs supporting MASH, serving as the nonclinical development line function lead on cross-functional program teams.
BiopharmaBiotechnologyMedical DevicePharmaceutical
Responsibilities
Serve as the nonclinical development line function lead on program teams, representing toxicology and ADME/DMPK in cross-functional decision-making
Develop and execute integrated nonclinical development strategies to support IND-enabling and clinical-stage programs in MASH
Provide scientific oversight of CRO-conducted studies, including protocol development, study monitoring, data review, interpretation, and reporting
Evaluate externally generated nonclinical data from acquired programs, identifying gaps, risks, and mitigation strategies
Interpret toxicology, toxicokinetic, and ADME data to support clinical dose selection, safety margins, and risk assessment
Contribute to the preparation, review, and approval of nonclinical sections of regulatory submissions, including INDs, amendments, and briefing packages
Partner closely with colleagues in pharmacology, clinical development, regulatory affairs, CMC, and project management to ensure alignment of nonclinical plans with program objectives and timelines
Qualification
Required
PhD (or equivalent) or Masters in Toxicology, Pharmacology, or a related scientific discipline
12-15 years of relevant pharmaceutical or biotechnology industry experience in nonclinical development
Late-stage small molecule development experience required
Demonstrated experience designing and overseeing nonclinical safety and ADME studies to support INDs and clinical development
Experience managing outsourced studies and working effectively with CROs and external partners
Strong written and verbal communication skills and ability to work effectively on cross-functional teams
Preferred
ADME and/or DMPK experience strongly preferred
Benefits
Flexible paid time off
Medical, dental, vision and life/disability insurance
401(k) offerings (i.e., traditional, Roth, and employer match)
Supplemental life insurance
Legal services
Mental health benefits through our Employee Assistance Program for employees and their family
Company
Madrigal Pharmaceuticals
Madrigal Pharmaceuticals is a biopharmaceutical company developing therapeutics for the treatment of cardiovascular-metabolic diseases.
501-1000 employees
H1B Sponsorship
Madrigal Pharmaceuticals has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2022 (1)
Funding
Current Stage
Public CompanyTotal Funding
$1.94BKey Investors
Blue OwlHercules Capital
2025-07-22Post Ipo Debt· $350M
2024-03-18Post Ipo Equity· $690M
2023-09-28Post Ipo Equity· $500M
Leadership Team
Mardi C. Dier
Chief Financial Officer
Carole Huntsman
Chief Commercial Officer (CCO)
Recent News
2026-01-19
Company data provided by crunchbase