Hinge Bio · 21 hours ago
Principal Scientist, Antibody Engineering
Redwood City, CA
Full-time
Onsite
Senior Level, Lead/Staff
5+ years expHinge Bio, Inc. is a privately-held biotechnology company leveraging its powerful GEM-DIMER™ platform to develop therapeutics that address the problems of resistance, inadequate efficacy, and side effects in the fields of inflammatory disease, cancer, and infectious disease. The company is seeking a creative and accomplished antibody engineering scientist to support the discovery and advancement of immunotherapy candidates to IND-filings for autoimmunity and oncology indications, contributing to all aspects of the programs from early discovery to development.
BiotechnologyLife ScienceMedical
Responsibilities
Lead design and in-house / outsourced production of Hinge Bio’s proprietary GEM-DIMER™ molecules, antibodies, Fc fusion proteins in collaboration with Protein Sciences Group
Work as part of a cross-functional team, characterizing leads with respect to protein purity, quality, binding activity, endotoxin, biological activity, etc
Interpret complex results and provide input supporting the discovery and preclinical development of GEM-DIMER™ candidates
Author publications and patents as required and present their research at scientific / medical conferences
Author / Co-Author reports contributing to IND filings
Ensure integrity, quality, and timely delivery of results
Qualification
Required
A Ph.D. in Biochemistry, Molecular Biology, Cell Biology, Immunology, or related field with at least 5-7 years of experience, preferably in industry
Hands on experience / advanced understanding of antibody engineering and protein purification methods
Knowledge and background in research and development of antibody therapeutics, experience coordinating CRO interactions
Excellent oral and written communication skills
Experience working within a collaborative, matrixed team - capable of effective project management including setting goals and priorities, planning, and executing research
Demonstrated scientific productivity as evidenced by a strong record of advancing drug development candidates, and/or through high-impact publications, presentations, and patents
A ‘get things done' mentality, proactive, enthusiastic, and goal oriented
Preferred
Experience with bi-specific or multi-specific antibody constructs
Knowledge of Fc receptor biology and applications to antibody design and therapeutic mechanisms
Understanding of antibody physicochemical properties and developability considerations / assays
Experience with biologics discovery related to autoimmune, oncology, and infectious disease indications
Experience in antibody discovery campaigns (phage display / yeast display, immunization, B cell cloning, hybridoma)
Experience with antibody humanization methods
Knowledge of target biology in one or more therapeutic areas
Working knowledge of analytical assays [affinity (SPR, ELISA), SEC, MS, stability assays]
Proficiency in flow cytometry methods
Company
Hinge Bio
Hinge Bio specializes in leveraging its proprietary Flex-Hinge antibody platform to develop bispecific and multispecific antibodies.
11-50 employees
Funding
Current Stage
Early StageTotal Funding
$30.22MKey Investors
Point72National Science Foundation
2025-01-15Series A· $30M
2018-05-22Grant· $0.22M
2018-01-01Series Unknown
Leadership Team
Carin Rollins
Co-Founder & COO
Kristen Quigley
Chief Clinical Operations Officer
Recent News
Labiotech UG
2025-11-08
Company data provided by crunchbase