Takeda · 9 hours ago
Global Therapeutic Research Lead - Oncology-Biologics
Cambridge, MA
Full-time
Hybrid
Director/Executive
15+ years expTakeda is a leading company in the biotech and pharmaceutical industry, seeking a Global Therapeutic Research Lead focused on oncology biologics. This role involves shaping the vision for oncology drug discovery and leading biologics programs from discovery through IND, while integrating innovative approaches and fostering external collaborations.
BiotechnologyHealth CareManufacturingMedicalPharmaceutical
Hiring Manager
Rania E.
Responsibilities
Ensure all programs have strong mechanistic rationale, clear differentiation hypotheses, and clinical line of sight
Integrate AI/ML and digital approaches into biologics drug discovery and help shape ODDU’s long-term research vision
Continuously assess the external oncology landscape to inform strategy and guide biologics portfolio evolution
Uphold scientific excellence, operational rigor, urgency, and a culture of innovation and high-quality decision-making
Extensive experience with bringing biologic drugs to IND in oncology. These include multi-specific antibodies, immune modulators, Fc- or payload-driven formats, and tumor-targeted therapies
Guide modality selection based on biology, mechanism, and clinical need
Own early asset strategy and lead cross-functional program teams from discovery through IND
Advance biologics programs through key milestones, including development candidate nomination and IND-enabling activities
Manage external partnerships to support high-confidence IND submissions and a sustainable research engine
Develop and communicate integrated program strategies across internal and external stakeholders
Mentor emerging scientific and operational leaders; develop biologics drug discovery capabilities across the organization
Foster a culture that encourages scientific rigor, constructive challenge, continuous learning, and urgency to advance impactful medicines to patients
Contribute to enterprise-level research initiatives and shape a broader organizational strategy
Represent Takeda and ODDU across academic, biotech, industry, and business development forums
Strengthen external collaborations that enhance innovation in biologics drug discovery and accelerate program execution
Participate in evaluating external innovation opportunities, including partnerships, collaborations, in-licensing, and acquisitions
Own progression, prioritization, and termination decisions for oncology biologics programs based on rigorous data-driven criteria
Promote early discontinuation of non-differentiated or insufficiently validated programs to maintain a high-impact research engine
Contribute to enterprise-level portfolio governance, strategic investment decisions, and long-range planning
Qualification
Required
Ph.D. or equivalent in life sciences
15+ years in discovery and preclinical development
10+ years in leadership
Deep oncology expertise with broad therapeutic awareness
Major contributions to multiple INDs
Proven track record advancing biologics oncology programs into the clinic
Deep expertise in antibody‑based and multifunctional biologics—including multi‑specifics, immune modulators, tumor‑targeted biologics, and Fc/payload‑enabled formats
Strong leadership in matrixed environments
Passion for AI/ML‑driven discovery
Proven ability to build, lead, and inspire high‑performing teams
Exceptional communication skills and external presence to advance programs and collaborations
Extensive experience with bringing biologic drugs to IND in oncology
Ability to guide modality selection based on biology, mechanism, and clinical need
Company
Takeda
Takeda is a biopharmaceutical company that researches and develops pharmaceutical drugs.
10001+ employees
H1B Sponsorship
Takeda has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (45)
2024 (39)
2023 (38)
2022 (34)
2021 (44)
2020 (18)
Funding
Current Stage
Public CompanyTotal Funding
$2.46B2025-06-27Post Ipo Debt· $2.4B
2016-09-01Grant· $19.8M
2016-05-08Grant· $38M
Leadership Team
Christophe Weber
President and CEO
Schuyler Fairfield
Senior Vice President, Global Head of Supply Chain
Recent News
2026-01-25
legacy.thefly.com
2026-01-23
2026-01-22
Company data provided by crunchbase