Manifold Bio · 3 hours ago
Director, Oligo Team Lead
Boston
Full-time
Onsite
Director/Executive
10+ years expManifold Bio is a dynamic biotech company focused on building a pipeline of targeted biologics. They are seeking an experienced drug development leader to guide the strategy and execution of their oligonucleotide therapeutics programs, combining technical and strategic leadership to advance drug discovery efforts.
BiotechnologyHealth CarePharmaceuticalTherapeutics
Responsibilities
Build and lead a fit-for-purpose oligonucleotide therapeutic discovery team that includes both internal and outsourced expertise and capabilities, as needed
Lead 1-2 cross-functional drug discovery project teams, collaborating closely with protein engineers, in vitro biologists, bioconjugation scientists, and in vivo biologists to discover and progress shuttled oligo-based therapeutics
Work with company leadership and cross-functional experts to prioritize high-value therapeutic targets for tissue-targeted oligo therapeutics
Define best-in-class target product profiles for tissue-targeted therapeutic oligonucleotides. Define workplans and track progress to deliver on those target product profiles
Closely track advances in the field and provide strategic direction for continued development and expansion of Manifold’s shuttled oligo discovery efforts
Clearly communicate scientific progress and challenges to team members, leadership, and internal/external collaborators
Establish and optimize innovative, efficient screening and production systems that leverage Manifold’s multiplexed in vivo screening capabilities
Serve as oligonucleotide therapeutic subject matter expert in discussions with potential partners, collaborators, and investors
Qualification
Required
PhD in a relevant field (chemistry, biochemistry, nucleic acid chemistry/biology, biophysics, molecular biology, pharmacology or related discipline)
Minimum of 10 years post-PhD experience, including experience in industry drug-discovery programs
Diverse experience with multiple oligonucleotide modalities (ASOs, siRNAs, aptamers, mRNA), different backbone chemistries/modifications
Knowledge of proven and emerging technologies for delivering oligo medicines to cellular targets (LNPs, passive or active targeting moieties, etc.)
Experience progressing oligonucleotide therapies from early discovery through IND-enabling preclinical activities / early clinical development
Demonstrated leadership of effective specialized and cross-functional scientific teams
Demonstrated ability to mentor junior scientists
Excellent written and verbal communication skills
Preferred
Experience designing and interpreting in vitro and in vivo systems assessing oligonucleotide efficacy and safety
Strong background in the engineering of optimized oligonucleotide conjugates, including linker discovery and bioconjugation optimization
Experience building and/or optimizing platforms for oligo design, synthesis, and screening
Understanding of DMPK, toxicology, developability, and CMC considerations specific to oligos
Track record of successful partnerships and external collaborations
Company
Manifold Bio
Manifold Bio is building a protein barcoding platform to bring the power of multiplexed measurement.
11-50 employees
H1B Sponsorship
Manifold Bio has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2024 (1)
2023 (1)
2021 (1)
Funding
Current Stage
Early StageTotal Funding
$46.4MKey Investors
Amazon Web ServicesTriatomic CapitalPlayground Global
2025-10-08Non Equity Assistance· $1M
2022-06-13Series A· $40M
2020-09-11Seed· $5.4M
Leadership Team
Gleb Kuznetsov
Co-Founder and CEO
Pierce Ogden
Co-Founder & CTO
Recent News
2026-01-11
2025-12-17
Business Wire
2025-12-15
Company data provided by crunchbase