Vertex Pharmaceuticals · 2 hours ago
Principal Engineer, Cloud Infrastructure
Boston, MA
Full-time
Hybrid
Senior Level, Lead/Staff
$144K/yr - $216K/yr
10+ years expVertex Pharmaceuticals is a global biotechnology company that invests in scientific innovation. The Principal Cloud Infrastructure Engineer will lead the design, implementation, and optimization of enterprise-scale Azure cloud infrastructure, focusing on automation and operational excellence.
BiotechnologyHealth CareMedicalPharmaceutical
Responsibilities
Lead the design and evolution of enterprise Azure infrastructure, including compute, storage, networking, and platform services
Define technical standards, reference architectures, and cloud-native patterns that align with business objectives, security requirements, and industry best practices
Serve as the primary technical authority for Azure infrastructure decisions
Drive automation-first initiatives across all infrastructure operations using tools such as Terraform, Azure DevOps, PowerShell, and Python
Design and implement CI/CD pipelines for infrastructure deployment, configuration management, and continuous compliance
Eliminate manual processes through intelligent automation and orchestration
Establish and optimize ITIL-aligned processes for incident, problem, change, and service request management within cloud environments
Ensure infrastructure operations meet SLA commitments and incorporate continuous service improvement practices
Partner with service management teams to enhance operational maturity
Identify and implement GenAI and Azure OpenAI capabilities to enhance infrastructure monitoring, incident resolution, capacity planning, and operational workflows
Develop AI-assisted automation solutions that improve mean time to resolution (MTTR) and enable predictive infrastructure management
Partner with Information Security, Compliance, and Privacy teams to ensure cloud infrastructure adheres to regulatory requirements, security frameworks, and data protection standards
Implement Azure Policies, landing zones, and governance controls that enforce compliance while enabling developer agility
Monitor, analyze, and optimize Azure infrastructure for performance, reliability, and cost efficiency
Utilize Azure Monitor, Log Analytics, and cost management tools to identify optimization opportunities
Implement FinOps practices to ensure cloud spending aligns with business value
Provide technical guidance and mentorship to infrastructure engineers and cross-functional teams
Lead architecture reviews, proof-of-concepts, and technical assessments
Foster a culture of innovation, learning, and engineering excellence within the infrastructure organization
Engage with Microsoft and technology partners to influence product roadmaps, participate in preview programs, and ensure enterprise needs are represented
Leverage Microsoft resources, including Unified Support and FastTrack, to accelerate cloud initiatives
Design and maintain robust disaster recovery and business continuity solutions using Azure Site Recovery, backup services, and multi-region architectures
Conduct regular DR testing and ensure infrastructure resilience meets business requirements
Qualification
Required
Bachelor's degree in Computer Science, Information Technology, Engineering, or related field
Typically requires 10+ years of experience in infrastructure engineering, cloud architecture, or the equivalent combination of education and experience
5+ years of hands-on experience with Microsoft Azure infrastructure and services
Proven track record of leading complex infrastructure projects in enterprise environments
Experience implementing automation frameworks and IaC practices at scale
Expert-level knowledge of Microsoft Azure services including Virtual Networks, Azure Kubernetes Service (AKS), Azure Virtual Machines, Storage, Azure Active Directory, and Azure Monitor
Deep expertise in infrastructure automation using Terraform, ARM templates, PowerShell, and Azure DevOps
Strong understanding of ITIL v4 framework and IT service management practices
Proficiency in scripting and programming languages (PowerShell, Python, Bash)
Knowledge of networking concepts, including VPN, ExpressRoute, DNS, load balancing, and firewall architectures
Understanding of security frameworks, compliance requirements (SOX, HIPAA, GxP), and zero-trust principles
Experience with monitoring and observability tools (Azure Monitor, Application Insights, Log Analytics, Grafana)
Experience with SaaS based virtual desktop solutions and corresponding profile management solutions (Azure Virtual Desktop, Windows 365, FSLogix)
Strong problem-solving abilities and capacity to troubleshoot complex technical issues
Excellent communication skills with ability to translate technical concepts for non-technical stakeholders
Preferred
Experience with AWS cloud infrastructure is strongly preferred
Familiarity with GenAI technologies, including Azure OpenAI Service and AI-assisted operations tools
Relevant certifications preferred: Azure Solutions Architect Expert, Azure DevOps Engineer Expert, or equivalent
Benefits
Medical, dental and vision benefits
Generous paid time off (including a week-long company shutdown in the Summer and the Winter)
Educational assistance programs including student loan repayment
A generous commuting subsidy
Matching charitable donations
401(k)
Company
Vertex Pharmaceuticals
Vertex Pharmaceuticals is focused on the discovery and development of small molecule drugs for the treatment of serious diseases.
5001-10000 employees
H1B Sponsorship
Vertex Pharmaceuticals has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (188)
2024 (150)
2023 (111)
2022 (164)
2021 (112)
2020 (80)
Funding
Current Stage
Public CompanyTotal Funding
$657.31MKey Investors
Janssen Belgium
2024-07-10Post Ipo Secondary· $1.11M
2022-05-17Post Ipo Equity· $50M
2009-12-03Post Ipo Equity· $443M
Leadership Team
Reshma Kewalramani
CEO and President
Nina Devlin
Senior Vice President, Chief Communications Officer
Recent News
2026-01-23
Benzinga.com
2026-01-23
2026-01-22
Company data provided by crunchbase