GSK · 16 hours ago
Director - Quantitative Systems Pharmacology
Collegeville, PA
Full-time
Onsite
Director/ExecutiveGSK is a global biopharma company aiming to positively impact the health of 2.5 billion people by the end of the decade. They are seeking a Director-level Quantitative Systems Pharmacologist Lead to join their newly established Department of Clinical Pharmacology and Quantitative Medicine, focusing on model-informed drug development and integration of scientific methodologies to enhance patient outcomes.
BiotechnologyHealth CarePharmaceutical
Responsibilities
Build and/or guide mathematical model development to understand disease, its progression, and drug action to prevent, treat and cure diseases; conduct simulations to assess trial design performance
Apply mechanistic models of biological, physiological, and pathophysiological processes to evaluate a disease, its pathways and progression, as well as drug candidates or treatment modalities
Develop and/or utilize state-of-the-art mathematical tools including knowledge of inverse-problem modelling and simulation, scientific ML and/or statistical techniques to gain insight into causal relationships between individual components of system-level and drug-level responses of drug-target-biomarker-disease-patient interaction
Define and execute a coordinated scientific and technical strategy (18-24 months planning horizon) with demonstrated ability to co-ordinate outputs from several expertise areas to determine strategy
Work in close collaboration with biologists, clinicians, clinical pharmacologists, pharmacometricians, statisticians, AIML, imaging, biomarker and other partner line colleagues to inform research and development programs and improve our understanding of disease mechanisms
Implement best practices, trends, lessons learned from internal and external sources to further clinical pharmacology modelling and simulation contributions to R&D pipeline
Create a collaboration framework with internal and external experts in the development and application of these models
Learn and apply emerging modeling and simulation methodologies with a view to enhance clinical program efficiency and investment decision quality; collaborate with external field-leading teams for methodology application
Able to efficiently and effectively interact with line and middle management, staff and external contacts on a functional, strategic and tactical level
Represent QSP CPQM on various internal advisory boards, companywide initiatives and/or leadership teams
Promote transparency and communicate R&D achievements through publications in appropriate scientific journals
Qualification
Required
PhD, MD, or PharmD with experience in mechanistic modelling and simulation and systems biology with applications in pharmaceutical research and development
Substantial experience in mechanistic mathematical modeling, inverse problem modeling and simulation, and/or scientific machine learning methodologies to apply to pre-clinical and/or clinical questions in drug development to solve practical problems in pharmaceutical industry
Strong drive and agility to quickly learn and build knowledge on a drug-disease system, the mechanism, endpoints, progression, prevention, treatments, and trial design
Demonstrated aptitude for productive collaboration in a multi-discipline team, using effective communication and taking personal accountability for timely delivery of results
Clear evidence of ability to make sound judgement in complex situations and adapt to changing business needs by prioritizing multiple tasks
Experience working with senior stakeholders in a cross functional environment
Track record of implementation of Model-Informed Drug Discovery and Development (MIDD) approaches to accelerate patient access to novel therapies and to expand therapeutic indications of marketed drugs
Preferred
Prior experience in Respiratory, Hepatology and/or Infections diseases is a plus
Company
GSK
We are uniting science, technology and talent to get ahead of disease together. Our community guidelines: https://gsk.to/socialmedia
Founded in 1929
10001+ employees
H1B Sponsorship
GSK has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (45)
2024 (56)
2023 (54)
2022 (53)
2021 (54)
2020 (72)
Funding
Current Stage
Public CompanyTotal Funding
$25.51MKey Investors
CARB-X
2021-03-02Grant· $18M
2020-09-23Grant· $7.51M
1978-01-13IPO
Leadership Team
Julie Brown
CFO
Mike Elmore
SVP & Chief Information Security Officer, GSK
Recent News
2026-01-16
2026-01-13
South China Morning Post
2026-01-08
Company data provided by crunchbase