TwoStep Therapeutics · 1 day ago
Chief Medical Officer
SF Bay Area
Full-time
Onsite
Director/Executive
15+ years expTwoStep Therapeutics is a biotechnology company focused on developing targeted cancer therapies. They are seeking a Chief Medical Officer (CMO) to lead the clinical development strategy for their pipeline of targeted drug conjugates and radioligand therapies, ensuring alignment with corporate goals and regulatory standards.
BiotechnologyHealth CareMedical
Responsibilities
Lead the overarching clinical development strategy and execution for the pipeline, ensuring seamless alignment with corporate goals, scientific innovation, and long-term patient impact
Serve as the primary medical expert for novel therapeutics to deliver rigorous, high-quality clinical, scientific, and regulatory outcomes
Collaborate closely with R&D, and external partners to align clinical strategies with corporate priorities, manufacturing capabilities, and development plans
Lead the preparation, review, and submission of critical regulatory documents (e.g., protocols, Investigator's Brochures) to enable efficient early-phase clinical development
Cultivate and maintain relationships with Key Opinion Leaders (KOLs), academic investigators, advisory boards, CROs, and trial sites
Engage effectively with investors, board members, and external stakeholders to communicate program progress, scientific rationale, and strategic value
Qualification
Required
Education: MD with board certification in a relevant specialty (e.g., oncology, nuclear medicine, radiation oncology, or related therapeutic area)
15+ years of progressive clinical leadership experience in the biotech or pharmaceutical industry, with a demonstrated track record of successfully advancing novel therapeutics from preclinical/early clinical stages through pivotal development
Proven expertise in global regulatory interactions, including successful submissions, negotiations, and approvals with major agencies (FDA, EMA, and others) across early and late-stage programs
Prior experience in a CMO, senior VP of Clinical Development, or equivalent medical leadership role in a biotech or pharmaceutical organization, ideally in a fast-paced, innovative environment
Hands-on, execution-oriented mindset with a willingness to actively contribute to pipeline advancement, including protocol design, data interpretation, and cross-functional problem-solving
Exceptional scientific judgment, strategic thinking, and communication skills
Preferred
Expertise with drug conjugates (i.e., peptide-drug conjugates, ADCs) and/or radioligand programs
Benefits
Competitive base salary, performance bonuses, and equity compensation
Unlimited Paid Time Off (PTO)
Comprehensive medical, dental, and vision benefits for individuals and families
401(k) plan
Company-paid basic life insurance
Company
TwoStep Therapeutics
TwoStep Therapeutics is developing novel tumor-targeting therapeutics for solid tumors.
2-10 employees
Funding
Current Stage
Early StageTotal Funding
$27.61M2026-01-20Series A· $21.11M
2024-06-25Seed· $6.5M
Leadership Team
Caitlyn Miller
Co-Founder & CEO
Recent News
2025-11-08
Company data provided by crunchbase