Revance · 14 hours ago
Principal Investigator, Downstream Process Development
Newark, CA
Full-time
Onsite
Senior Level, Lead/Staff
$16K/yr - $185K/yr
5+ years expRevance is a fast-growing global aesthetics and skincare company focused on providing innovative aesthetics and market-leading skincare offerings. The Principal Investigator will lead scientific studies for the development and optimization of purification processes for protein biologic compounds, manage a team of scientists, and improve manufacturing processes through data analysis and technology transfers.
BiotechnologyHealth CarePharmaceuticalTherapeutics
Responsibilities
Independently lead and execute Purification Process characterization and development studies
Install and use of process development equipment, assay, and data analysis technology
Transfer scientific knowledge and hands-on experience to downstream development and manufacturing teams
Look for new equipment, methods, and strategies to introduce into new and existing technologies
Monitor and analyze manufacturing data to provide support for discrepancy investigations, process step validation, process improvements, or equipment troubleshooting
Create scientifically sound hypotheses using literature information, experimental results, and novel approach to old concepts
Conduct statistical evaluation of historical process parameters and refine design space with additional DOE experiments to establish robust process control strategy
Conducting experiments for process characterization and assessment of critical process parameters
Contribute to teamwork through lab-based activities
Cross-functional interaction with Quality and other departments
Technical support of ongoing GMP production and technology transfer to GMP environment
Execution of projects to reduce discrepancies and increase safety/compliance
Assignment and execution of tasks in rapidly changing environment according to priorities
Support of regulatory inspections and filings
Authorship of technical reports, presentations
Collaborate in publishing of papers and presentation of work at scientific conferences
Representation of downstream team expertise during cross-functional CMC meetings
Supervise a downstream team, ensure, and evaluate performance and effectiveness of direct reports and support career development
Qualification
Required
Ph.D. in Biochemistry, Chemical Engineering, or a related discipline, with 5+ years industry experience
M.S. with 7+ years industry experience
B.S. with 10+ years industry experience
At least 5-10 years of pharma/biotech industry experience with understanding of integration of functions within pharmaceutical industry
Both practical experience with and theoretical knowledge of engineering principles involved in scaling process from development lab to pilot/manufacturing scale
In-depth protein purification knowledge and experience, including familiarity with AKTA lab-scale and preparative chromatography systems and Unicorn software
Experience with TFF process development: membrane selection, pressure, cross and flux flow rates
Experience with separation, centrifugation, and filtration operations (depth, dead-end, and TFF)
Proficiency in column-based analytical methods SEC, HIC, IEX, RP; analytical methods such as Mass Spec, binding affinity, or activity assays, SDS-PAGE, Western blotting, IEF
Capable of integrating complex pieces of information and providing a cohesive interpretation
Rigorous attention to the details of experimental protocols
Ability to comprehensively document in writing the details of each experimental operation
Preferred
Pharmaceutical process or product development experience is a plus
Excellent oral presentation and written communication skills are a must
Good record keeping skills and attention to detail are essential
Experimental work and statistical analysis of data required
Proficient in Microsoft Office
Advanced Excel skills required
Benefits
Competitive Compensation including base salary and annual performance bonus.
Flexible PTO, holidays, and parental leave.
Generous healthcare benefits, HSA match, 401k match, employer paid life and disability insurance, pet insurance, wellness discounts and much more!
Company
Revance
We believe that science-powered innovation creates possibilities.
1001-5000 employees
H1B Sponsorship
Revance has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (12)
2024 (16)
2023 (8)
2022 (10)
2021 (16)
2020 (3)
Funding
Current Stage
Public CompanyTotal Funding
$1.68BKey Investors
Athyrium Capital Management LPEssex Woodlands Healthcare PartnersMedicis Pharmaceutical
2024-08-12Acquired
2024-03-04Post Ipo Equity· $100M
2022-09-12Post Ipo Equity· $200M
Leadership Team
Nadeem Moiz
Chief Executive Officer
Steve Kreider
Executive Vice President, Chief Revenue Officer - Aesthetics and Therapeutics
Recent News
MarketScreener
2025-10-27
Company data provided by crunchbase