Flagship Pioneering · 16 hours ago
Principal Scientist, In Vitro Pharmacology
Boston, MA
Full-time
Onsite
Senior Level, Lead/Staff
$163K/yr - $214K/yr
7+ years expAbiologics, Inc. is a privately held biotechnology company on a mission to innovate therapeutic modalities. They are seeking a Principal Scientist to lead in vitro pharmacology efforts, develop and execute pharmacology plans, and mentor junior scientists while collaborating with cross-functional teams.
FinanceFinancial ServicesVenture Capital
Responsibilities
Design, develop and execute cell-based assays to assess SynteinTM activity, target engagement and mechanism of action to drive discovery programs
Lead cell biology efforts within the Pharmacology team to identify and implement relevant cell-based assays for diverse target classes and disease areas
Lead a cross-functional project team, including driving strategy for progressing multiple hit series
Collaborate with the Pharmacology team on biochemistry and biophysics projects and provide cell biology expertise and guidance to junior team members
Contribute to in vivo and ex vivo pharmacology activities to progress projects and the platform
Collaborate cross-functionally to enable novel methods, assays and screening workflows
Ensure rapid generation and accurate reporting of high-quality data and collaborate with Computational Design and Chemistry teams to drive design-make-test cycles
Effectively communicate scientific findings and ideas to a diverse team both informally and at project team meetings
Qualification
Required
PhD in molecular or cell biology or related discipline with minimum 7+ years relevant experience (with at least 5 in industry) required
Technical expertise with mammalian cell culture including establishing and maintaining cell lines, transient and stable transfection, lentiviral transduction, and reporter cell lines
Proficient in industry-standard cell-based assays and bioanalytical techniques including TR-FRET, ELISA, Western blot, flow cytometry, and reporter gene assays; experience with cellular/high content imaging and image analysis a plus
Experienced with primary cell culture and characterization, including tissue dissociation
Experienced in assay development and testing in model systems and human with good understanding of analytical and pre-analytical methods and solutions
Demonstrated ability to independently design, develop and optimize diverse cell-based functional assays (e.g., intracellular signaling) and interpret complex results
Industry level experience with best practices related to data records creation and maintenance and workflow integrity
Demonstrated ability to work in a fast-paced environment; self-driven, creative, with a strong team-oriented mentality
Demonstrated ability to lead and grow people in the industry setting
Preferred
In vivo pharmacology expertise highly desired
Disease biology expertise in oncology is highly desirable, with experience advancing compounds from discovery through preclinical development
Proficiency in laboratory automation and semi-automated screening workflows a plus
Benefits
Healthcare coverage
Annual incentive program
Retirement benefits
A broad range of other benefits
Company
Flagship Pioneering
Flagship Pioneering is a venture capital firm that invests in life sciences and healthcare companies.
501-1000 employees
H1B Sponsorship
Flagship Pioneering has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (8)
2024 (4)
2023 (4)
2022 (4)
2021 (1)
Funding
Current Stage
Late StageLeadership Team
Noubar Afeyan
Founder and CEO
Chuck Carelli
Chief Financial Officer
Recent News
2026-01-16
2026-01-16
Company data provided by crunchbase