Sanofi · 15 hours ago
Senior Principal Scientist
Cambridge, MA
Full-time
Onsite
Senior Level, Lead/Staff
$148K/yr - $214K/yr
7+ years expSanofi is an R&D-driven, AI-powered biopharma company committed to improving people’s lives. As a Senior Principal Scientist, you will lead transformative drug discovery efforts for patients with rare Mendelian disorders, driving innovation from target identification through clinical candidate selection.
Health CareLife SciencePharmaceuticalTherapeutics
Responsibilities
Build drug discovery programs employing a variety of therapeutic modalities (small molecule, biologics, antisense oligonucleotides, gene therapy, etc.) targeting metabolic and mitochondrial disorders
Define research strategy and drive decision-making for rare disease programs from target validation through IND-enabling studies
Serve as the scientific voice for programs in governance forums, providing strategic recommendations that shape portfolio priorities
Identify and evaluate emerging therapeutic opportunities in metabolic and mitochondrial diseases through competitive intelligence and scientific landscape analysis
Design and oversee the execution of sophisticated in vitro and in vivo studies to elucidate disease mechanisms, validate therapeutic targets, and establish proof-of-concept for novel interventions
Drive mechanistic understanding of rare metabolic disorders
Integrate multi-omics approaches and systems biology to identify disease drivers and therapeutic intervention points
Translate preclinical findings into clinical development strategies in collaboration with translational medicine teams
Lead or contribute to cross-functional project teams spanning discovery research, translational medicine, clinical development, and regulatory affairs
Build and maintain strategic relationships with leading academic researchers, clinician-scientists, and patient advocacy organizations in the rare metabolic disease community
Manage external collaborations including CROs, academic partnerships, and biotech alliances to accelerate program advancement
Represent Sanofi's scientific leadership at conferences, advisory boards, and collaborative research forums
Generate rigorous data analyses, interpretations, and documentation to support program milestones, regulatory submissions (IND/CTA), patent filings, and publications
Communicate complex scientific concepts clearly and persuasively to diverse audiences including senior leadership, external collaborators, and the broader scientific community
Mentor and develop junior scientists, fostering a culture of scientific excellence and innovation
Qualification
Required
Ph.D. or equivalent advanced degree in biochemistry, metabolism, mitochondrial biology, molecular/cellular biology, genetics, or related discipline
Minimum of 7+ years of post-graduate experience in academic or biopharmaceutical research, with substantial focus on metabolic and/or mitochondrial disorders
Deep expertise in neurological, neuromuscular, metabolic, and/or mitochondrial disorders
Proven drug discovery leadership experience in industry with a track record of contributions to multidisciplinary teams and advancing therapeutic programs toward clinical development
Preferred
Demonstrated contributions to IND/CTA-enabling activities, including target validation, mechanism-of-action studies, biomarker development, and translational research
Strong publication record in high-impact journals demonstrating scientific thought leadership in relevant disease areas
Established network within the academic, clinical, and patient advocacy communities focused on rare metabolic and mitochondrial diseases
Experience with relevant disease models including patient-derived cells, organoids, and animal models
Expertise designing and incorporating metabolomics, lipidomics, or other specialized experimental modalities
Familiarity with computational biology, bioinformatics, or analysis of large-scale 'omics datasets
Experience with multiple therapeutic modalities and platform technologies
Prior involvement in regulatory document preparation and interactions with health authorities
Understanding of the rare disease drug development landscape, including regulatory pathways and reimbursement considerations
Experience presenting at scientific conferences and contributing to the external scientific discourse in rare diseases
Benefits
High-quality healthcare
Prevention and wellness programs
At least 14 weeks’ gender-neutral parental leave
Company
Sanofi
Sanofi is a global biopharma company focused on prescription drugs, vaccines, and treatments for chronic, rare, and infectious diseases.
10001+ employees
H1B Sponsorship
Sanofi has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (101)
2024 (68)
2023 (59)
2022 (78)
2021 (38)
2020 (38)
Funding
Current Stage
Public CompanyTotal Funding
$6.97BKey Investors
Blackstone Life SciencesEvotec
2025-10-28Post Ipo Debt· $3B
2025-06-17Post Ipo Debt· $1.74B
2025-03-05Post Ipo Debt· $1.59B
Leadership Team
Paul Hudson
Chief Executive Officer
Francois-Xavier Roger
Chief Financial Officer
Recent News
2026-01-25
BioWorld Financial Watch
2026-01-25
2026-01-24
Company data provided by crunchbase