Merck · 9 hours ago
Senior Scientist, Enzyme Kinetics
Lansdale, PA
Full-time
Hybrid
Mid, Senior Level
$117K/yr - $184K/yr
4+ years expMerck is seeking a collaborative and self-motivated Senior Scientist to join the Drug Metabolism and Pharmacokinetics Group. The main goal of this position is to support the advancement of drug candidates through characterization of absorption, distribution, metabolism, and elimination properties of therapeutics, while providing enzymology expertise and designing experiments.
BiotechnologyHealth CareMedicalPharmaceutical
Responsibilities
Support the advancement of drug candidates through characterization of absorption, distribution, metabolism, and elimination (ADME) properties of therapeutics
Provide enzymology expertise and independently design and execute experiments utilizing in silico, in vitro, and in vivo methodologies to assess drug disposition and drug-drug interaction risk
Contribute to decision-making for lead discovery and development
Set high standards for scientific rigor and timely delivery of results while collaborating with colleagues to drive operational impact
Qualification
Required
Bachelor's degree with 7–9+ years relevant experience, master's degree with 4–6+ years relevant experience, or Ph.D. with 0–4 years relevant experience in analytical chemistry, biochemistry, pharmaceutical sciences, pharmacology, enzymology or a related scientific discipline
Experience performing enzyme kinetics experiments and kinetic data analysis to address mechanistic questions that inform project decision‑making
Hands‑on experience with quantitative bioanalysis (LC‑MS/MS or equivalent) for drugs and biological molecules
Proficiency in data analysis and documentation tools (Excel, GraphPad Prism, electronic lab notebooks; familiarity with Spotfire or similar platforms preferred)
Strong problem solving, attention to detail, autonomy, critical thinking, and growth mindset; demonstrated ability to prioritize, plan with ownership and accountability to deliver high quality results on time
Excellent interpersonal and communication skills; with a track record of collaborating effectively within cross‑functional teams and presenting results to project stakeholders
Preferred
Proven ability to design, execute and interpret in vitro ADME/DMPK studies (e.g. metabolic stability, substrate phenotyping, inhibition, induction, protein binding) using tissues, cell systems, subcellular fractions, and recombinant enzymes
Experience supporting projects across multiple therapeutic areas and modalities (e.g. small molecules, peptides, biologics)
Experience handling radiolabeled materials, tissue preparations, and biological matrices
Experience developing or implementing automation for in vitro ADME assays and leveraging informatics platforms for data collation/interpretation
Prior experience in a research‑driven pharmaceutical or biotech environment
Demonstrated mentoring experience with associate scientists
Understanding of regulatory guidance for in vitro DDI risk assessment and translating results to program teams
Familiarity with translational/in vivo study design or integration of in vitro–in vivo data to support pharmacokinetic and safety assessment
Benefits
Medical
Dental
Vision healthcare and other insurance benefits (for employee and family)
Retirement benefits, including 401(k)
Paid holidays
Vacation
Compassionate and sick days
Company
Merck
Merck is a biopharmaceutical company that offers medicines and vaccines for various diseases.
10001+ employees
Funding
Current Stage
Public CompanyTotal Funding
$5.59MKey Investors
Private Capital AdvisorsGavi, the Vaccine Alliance
2018-11-25Post Ipo Equity· $0.59M
2016-01-21Series Unknown· $5M
1980-12-19IPO
Leadership Team
Betty Larson
Executive Vice President and Chief Human Resources Officer
Dean Li
Executive Vice President and President, Merck Research Laboratories
Recent News
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