Altos Labs · 9 hours ago
Scientist / Senior Scientist, DMPK
San Francisco, CA
Full-time
Onsite
Mid, Senior Level
$146K/yr - $247K/yr
3+ years expAltos Labs is dedicated to restoring cell health and resilience through cell rejuvenation. They are seeking a Scientist or Senior Scientist to join their Drug Metabolism and Pharmacokinetics (DMPK) team, where the successful candidate will provide DMPK support for therapeutic programs across various modalities, ensuring high-quality decision-making through data interpretation.
BiopharmaBiotechnologyHealth CareHealth DiagnosticsMedical
Responsibilities
Serve as the DMPK representative on cross-disciplinary preclinical project teams, providing strategic and data-driven DMPK guidance to advance portfolio programs
Plan, manage, and oversee ADME and PK studies executed with external CRO partners
Partner with Medicinal Chemistry to develop ADME- and PK-driven SAR strategies to optimize candidate properties and progression
Collaborate with Pharmacology and the internal DMPK bioanalysis group to design, execute, and interpret preclinical PK/PD, target engagement, and efficacy studies
Calculate the projected efficacious human dose to support IND-enabling development and regulatory submissions
Provide DMPK support to early-stage, pre-portfolio discovery programs, helping shape strategy and experimental plans
Advise and train the DMPK bioanalysis team to support internalization and implementation of select ADME assays
Stay current on emerging DMPK science and best practices through literature review and participation in relevant scientific meetings
Qualification
Required
PhD in Chemistry, Biology, Pharmaceutical Sciences, or a related field and 3+ years of relevant work experience
Strong fundamental knowledge of DMPK and ADME
Working knowledge of ADME assays and bioanalysis, leveraged to design studies and interpret data
Ability to evaluate in vitro-in vivo correlation of drug candidates across preclinical species
Ability to generate NCA and compartmental PK models; general knowledge of mechanistic modeling concepts (e.g., PBPK)
Ability to communicate DMPK results in a timely, clear, and impactful manner to non-DMPK scientists
Exceptional organizational skills, attention to detail, time management, and ability to work independently and collaboratively
Willingness to gain new knowledge and apply it to support multiple therapeutic modalities
Preferred
Knowledge and experience using RStudio, CDD, or similar platforms
Prior DMPK experience and expertise in one of the following: therapeutic proteins/biologics or small molecule metabolism
Although this position will not be lab-facing, experience with LC-MS for ADME and/or bioanalysis is desirable
Company
Altos Labs
Altos Labs focuses on cellular rejuvenation programming to restore cell health and resilience, to reverse disease to transform medicine.
201-500 employees
H1B Sponsorship
Altos Labs has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (8)
2024 (7)
2023 (5)
2022 (6)
Funding
Current Stage
Growth StageTotal Funding
$3B2021-09-06Series A· $3B
Leadership Team
Joan Mannick
Chief Medical Officer
Recent News
2026-01-06
Genetic Engineering News
2025-12-10
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