Thermo Fisher Scientific · 6 hours ago
Manufacturing Engineer III
Mebane, NC
Full-time
Onsite
Senior Level
5+ years expThermo Fisher Scientific is a leading company dedicated to making the world healthier, cleaner, and safer. The Manufacturing Engineer III role involves owning the end-to-end performance of high-throughput molding and automation cells, leading cross-functional execution, and managing multiple projects to improve operational efficiency and product quality.
BioinformaticsBiotechnologyCloud Data ServicesConsultingHealth CareLife ScienceManagement Information SystemsOffice SuppliesPrecision Medicine
Responsibilities
Own end-to-end performance of high-throughput molding/automation cells or lines with minimal oversight
Set technical direction, lead cross-functional execution, and deliver measurable gains in OEE, FPY, scrap, cycle time, changeover, MTBF/MTTR, and uptime
Shape capacity and capital strategies; manage multiple projects from scope to sustainment
Specify, integrate, and sustain sensors, actuators, conveyors, pick-and-place, and vision systems; drive HMI updates and PLC change requests with proper version/recipe control and I/O checkout
Lead troubleshooting of chronic automation faults; implement upgrades using downtime Pareto and failure-mode data
Optimize PM/predictive maintenance with Reliability Engineering; analyze CMMS data to increase MTBF and reduce MTTR
Define critical spares strategy (criticality, usage, lead time); set reorder points aligned to OEE targets
Implement error-proofing, interlocks/Jidoka, and inline vision to prevent defects and protect equipment
Author and maintain PFMEA, Control Plans, Process Flows, and reaction plans; define and achieve process capability targets
Execute DOE, capability studies, SPC, and RCCM/8D; reduce OOC events and prevent recurrence
Lead IQ/OQ/PQ and FAT/SAT; deliver audit-ready validation packages and controlled production release
Manage ECN/ECO with risk assessment and required revalidation
Ensure GDP, manage MCPs, deviations, NCRs, and close CAPAs with verified effectiveness
Own MSA (GR&R); maintain gauge inventory and calibration
Act as manufacturing lead for NPI, owning industrialization from pilot through ramp
Define manufacturing requirements, automation concepts, and process capability targets aligned to product CTQs
Drive DFM/DFA with product engineering; perform tolerance stack-ups and manufacturability reviews; influence design to meet yield, cycle time, and cost goals
Plan and execute process qualifications, capacity validation, and ramp-to-rate; coordinate tooling/fixture/automation readiness, FAT/SAT, and IQ/OQ/PQ
Establish production control plans, standard work, training, and spare strategies before launch; stabilize post-launch with data-driven improvements
Maintain and improve technical Standard Work, work instructions, routings/BOMs, and line balance to meet takt and safety
Build performance dashboards from MES/ERP and CMMS; drive daily management and action logs
Lead kaizen (VSM, SMED, 5S, Visual Management, A3) delivering quantified throughput, changeover, quality, and safety gains
Define readiness gates and exit criteria; develop charters, schedules, risks, and business cases; ensure benefits realization
Operate independently on ambiguous automation/process challenges; define approach, timeline, and success metrics; proactively mitigate risks
Act as technical hub for assigned assets across operations, quality, reliability, supply chain, EHS, and vendors; represent Manufacturing in audits and reviews
Mentor Engineers I–II and technicians; review standard work and validation for rigor; establish best practices and training for automation operations and troubleshooting
Qualification
Required
Bachelor's in Manufacturing, Mechanical, Industrial Engineering, or related
5–8 years in automated/high-throughput manufacturing with proven OEE/FPY improvements and scrap, cycle time, changeover, and reliability gains
Proficient in PFMEA, Control Plans, DOE, SPC, MSA, IQ/OQ/PQ; strong technical documentation
Hands-on with automation/controls (vision, sensors, conveyors, pick-and-place, HMI/PLC change control) and production troubleshooting
Lean/Six Sigma (VSM, SMED, 5S, A3, Visual Management); tools: MES/ERP, CMMS, CAD, Minitab, Power BI
Strong cross-functional influence and vendor/integrator management
Excellent technical writing for standard work and validation reports; effective cross-functional communication
Preferred
High-volume production experience in life sciences, injection molding, clean room, or regulated/heavily automated industries
Proven track record of improving manufacturing performance using statistical methods and lean tools
Certification(s): Lean Six Sigma Green Belt, CMfgE
Experience with MES/ERP, CMMS, CAD and data tools (Minitab, Power BI)
Company
Thermo Fisher Scientific
Thermo Fisher Scientific is a biotechnology and laboratory equipment company that provides a wide range of scientific products and services.
10001+ employees
H1B Sponsorship
Thermo Fisher Scientific has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (272)
2024 (224)
2023 (233)
2022 (342)
2021 (315)
2020 (227)
Funding
Current Stage
Public CompanyTotal Funding
$15.97BKey Investors
National Grid
2025-11-24Post Ipo Debt· $2.42B
2025-09-30Post Ipo Debt· $2.5B
2023-08-07Post Ipo Debt· $2.95B
Leadership Team
Stephen Williamson
Senior Vice President and Chief Financial Officer
Michel Lagarde
Chief Operating Officer
Recent News
CB Insights
2026-01-23
Company data provided by crunchbase