Allergan Aesthetics, an AbbVie Company · 14 hours ago
Senior Scientist I, Pipeline Development & Targeted Delivery
Cambridge, MA
Full-time
Onsite
Senior Level, Lead/Staff
$94K/yr - $178K/yr
8+ years expAbbVie is a global biopharmaceutical company committed to bringing innovative medicines to patients in need. We are looking for a Senior Scientist I to join our siRNA group within the Biotherapeutics and Genetic Medicine department, focusing on advancing RNA-based therapies and addressing scientific challenges related to oligonucleotide therapeutics.
BeautyManufacturingPharmaceuticalWellness
Responsibilities
Lead research efforts within a cross-functional team to advance new therapeutic targets for siRNA-based pipeline development
Design and execute *in vitro* and *in vivo* proof-of-concept studies to evaluate novel extrahepatic, targeted siRNA delivery platforms across multiple pipeline programs
Design and execute receptor expression profiling, ligand–receptor binding, internalization, and trafficking assays
Evaluate functional delivery and target knockdown in receptor-positive cells and tissues
Provide scientific leadership and expertise in candidate nomination and pipeline development
Work independently and maintain a high level of productivity in the laboratory, ensuring efficiency and scientific rigor
Analyze and interpret multidisciplinary data to generate actionable conclusions and guide future experimental directions
Collaborate and effectively communicate results with key stakeholders and cross-functional teams throughout the organization
Contribute as a primary author to scientific publications, presentations, and/or as a primary inventor of patent applications
Mentor and support junior scientists within the team
Qualification
Required
BS, MS, or PhD in chemistry, biology, biochemistry, pharmacology or related field with typically 10+ years (BS), 8+ years (MS), or 0-3 years (PhD) of experience
Demonstrated expertise in siRNA candidate nomination and pipeline development
Demonstrated experience in drug delivery platforms, receptor biology and targeted delivery
Hands on experience of uptake, trafficking, and functional delivery assays
Extensive hands-on experience and techniques for molecular and RNA biology, including cell culture, RNA extraction, RNA quantification (RT-PCR, qPCR, ddPCR), next-generation sequencing (NGS) library preparation, protein assays (ELISA, Western Blot, JESS), flow cytometry and other biomarker quantification
Proven ability to develop, troubleshoot and refine assays to enhance sensitivity, reproducibility, and throughput
Highly self-motivated and capable of thriving in a fast-paced, collaborative team environment
Strong written and verbal communication skills, with experience contributing to technical reports, publications, or regulatory documentation
Preferred
Experience in assay development and high-throughput screening for siRNA target identification and validation, mechanism of action studies, biodistribution and biomarker analysis is a plus
Benefits
Paid time off (vacation, holidays, sick)
Medical/dental/vision insurance
401(k)
Short-term incentive programs
Company
Allergan Aesthetics, an AbbVie Company
At Allergan Aesthetics, an AbbVie company, we develop, manufacture, and market a portfolio of leading aesthetics brands and products.
1001-5000 employees
H1B Sponsorship
Allergan Aesthetics, an AbbVie Company has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2024 (1)
2023 (1)
2022 (16)
2021 (14)
2020 (5)
Funding
Current Stage
Late StageLeadership Team
Nicole Mowad-Nassar
Senior Vice President, AbbVie and President, Global Allergan Aesthetics
Recent News
2025-12-04
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