Foresite Labs · 1 day ago
Sr Principal Engineer, Mechanical Engineering
San Diego
Full-time
Onsite
Senior Level, Lead/Staff
$250K/yr - $280K/yr
15+ years expForesite Labs is seeking a highly experienced engineer to serve as their Mechanical Engineering Lead, focusing on Precision Motion, Precision Machine Design, and Automation Systems. The role involves driving architecture evaluation, developing detailed product designs, and integrating hardware with software and firmware for robust system performance.
BiopharmaBiotechnologyHealth CareMedical
Responsibilities
Establish clear requirements for the Mechanical Sub-Systems, collaborating closely with cross-functional stakeholders
Drive key architecture decisions for Precision Motion, Precision Machine Design, and Automation Systems
Serve as the highest-level owner of the detailed design of the Mechanical Sub-Systems, establishing clear specifications for the hardware and operational workflow that enable robust, reliable operation
Own the integration and bring-up of the Mechanical Sub-Systems including hardware, software, and firmware integration. This includes supporting the development of detailed definitions of operational workflows, including exceptions and error handling
Develop metrology to measure the performance of the Mechanical Sub-Systems
Own the Engineering Verification Testing demonstrating that sub-system requirements are met
Lead Tiger Teams, as necessary, to debug the most complex issues
Contribute to the company’s intellectual property, especially in selecting optimal system architectures
Qualification
Required
Advanced degree (MS or Ph.D.) in Mechanical Engineering, Applied Physics, or a related field
15+ years of leadership experience in complex instrument development within life sciences, semiconductor, diagnostics, or imaging systems
Deep technical expertise in mechanical engineering, with specific experience developing precision motion systems and precision mechanisms
Strong track record of effective collaboration across cross-functional disciplines through effective communication and first-order modeling
Preferred
Experience with automated optical or biochemical instruments for molecular diagnostics or high-throughput screening
Familiarity with regulatory and quality considerations for life science instruments
Company
Foresite Labs
Foresite Labs is a biotechnology company. It is a sub-organization of Foresite Capital.
11-50 employees
H1B Sponsorship
Foresite Labs has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (2)
2022 (1)
Funding
Current Stage
Early StageLeadership Team
Alex Blocker
CTO and Chief Data Scientist
Uplaksh Kumar
COO Foresite Labs and Venture Partner Foresite Capital
Recent News
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2026-01-02
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2025-11-19
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2025-11-17
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