AbbVie · 2 hours ago
Senior Scientist I, Pipeline Development & SAR Optimization
Cambridge, MA
Full-time
Onsite
Senior Level, Lead/Staff
8+ years expAbbVie is a global biopharmaceutical company dedicated to innovative medicines and solutions. They are seeking a Senior Scientist I to join their siRNA group, focusing on advancing RNA-based therapies and addressing scientific challenges related to oligonucleotide therapeutics.
BiotechnologyFinancial ServicesHealth CareMedicalPharmaceuticalVenture Capital
Responsibilities
Lead research efforts within a cross-functional team to advance new therapeutic targets for siRNA-based pipeline development
Design and execute in vitro and in vivo proof-of-concept studies to evaluate siRNA library and characterize lead compounds for the target engagement and therapeutic benefits
Design and execute structure-activity-relationship (SAR) studies for lead optimization, including optimization of siRNA sequence, chemical modification patterns, conjugation sites and linkers, etc
Provide scientific leadership and expertise in candidate nomination and pipeline development
Work independently and maintain a high level of productivity in the laboratory, ensuring efficiency and scientific rigor
Analyze and interpret multidisciplinary data to generate actionable conclusions and guide future experimental directions
Collaborate and effectively communicate results with key stakeholders and cross-functional teams throughout the organization
Contribute as a primary author to scientific publications, presentations, and/or as a primary inventor of patent applications
Mentor and support junior scientists within the team
Qualification
Required
BS, MS, or PhD in chemistry, molecular biology, biochemistry, or related field with typically 10+ years (BS), 8+ years (MS), or 0-3 years (PhD) of experience
Demonstrated expertise in siRNA therapeutics, including library design, screening and characterization of SAR
Demonstrated expertise for siRNA candidate nomination and pipeline development
Extensive hands-on experience and techniques for molecular and RNA biology, including cell culture, RNA extraction, RNA quantification (RT-PCR, qPCR, ddPCR), next-generation sequencing (NGS) library preparation, protein assays (ELISA, Western Blot, JESS), flow cytometry and other biomarker quantification
Proven ability to develop, troubleshoot and refine assays to enhance sensitivity, reproducibility, and throughput
Highly self-motivated and capable of thriving in a fast-paced, collaborative team environment
Strong written and verbal communication skills, with experience contributing to technical reports, publications, or regulatory documentation
Preferred
Experience in assay development and high-throughput screening for siRNA target identification and validation, mechanism of action studies, biodistribution and biomarker analysis is a plus
Strong understanding of ex-hepatic delivery of siRNA is highly desirable
Benefits
Paid time off (vacation, holidays, sick)
Medical/dental/vision insurance
401(k)
Company
AbbVie
AbbVie is a biopharmaceutical company focused on immunology, oncology, neuroscience, virology, and aesthetics. It is a sub-organization of AbbVie.
10001+ employees
H1B Sponsorship
AbbVie has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (273)
2024 (190)
2023 (225)
2022 (284)
2021 (186)
2020 (186)
Funding
Current Stage
Public CompanyTotal Funding
$15B2024-02-27Post Ipo Debt· $15B
2023-03-08Post Ipo Equity· $0.25M
2012-12-20IPO
Leadership Team
Robert Michael
Chairman of the Board and Chief Executive Officer
Micah Bregman
Vice President, Global Strategy and Pipeline, Allergan Aesthetics
Recent News
2026-01-23
2026-01-20
2026-01-20
Company data provided by crunchbase